Transforming Growth Factor-β1 Gene Polymorphism (T29C) in Egyptian Patients with Hepatitis B Virus Infection: A Preliminary Study

Table 1

Demographic and biochemical characteristics of HBV patients and healthy controls.

Parameter	Control group; (𝑁=65)	HBV group; (𝑁=50)	P	Correlation with disease
Demographic data
Age (mean ± SD)	44.92±11.76	32.11±14.89	NS	𝑟=0.437; 𝑃<0.001
Gender (Male ♂: Female ♀)	53/12; (81.5/18.5%)	14/36; (28%/72%)	𝑃<0.001	𝑟=0.523; 𝑃<0.001
Laboratory investigations (mean ± SD)
AST (IU/L)	41.59±3.47	22.18±1.05	𝑃<0.001	𝑟=0.473; 𝑃<0.001
ALT (IU/L)	44.49±5.61	16.74±0.86	𝑃<0.01	𝑟=0.455; 𝑃<0.001
Albumin (g/L)	3.37±0.12	4.35±0.07	𝑃<0.01	𝑟=−0.625; 𝑃<0.001
Total bilirubin (mg/dL)	1.03±0.08	0.70±0.04	𝑃<0.05	𝑟=0.381; 𝑃<0.01
Direct bilirubin (mg/dL)	0.25±0.06	0.12±0.03	𝑃<0.05	𝑟=0.198; NS
Creatinine (mg/dL)	1.11±0.06	0.89±0.03	𝑃<0.01	𝑟=0.332; 𝑃<0.01
Urea (mg/dL)	33.16±2.26	29.85±1.41	𝑃<0.01	𝑟=0.130; NS
HBV DNA (IU/L)	—	1003076.02±914392.11	—	𝑟=0.168; 𝑃<0.05

All data are presented as mean ± SD. Alanine aminotransferase (ALT); Aspartate aminotransferase (AST).