Involvement of Differential Relationship between HCV Replication and Hepatic PRR Signaling Gene Expression in Responsiveness to IFN-Based Therapy

Table 2

Correlations between HCV replication (liver positive- and negative-strand HCV RNAs and circulating HCV RNA) and hepatic PRR signaling gene expression regarding virologic response at week 24.

Hepatic gene expression		Responders at week 24 (𝑛=26)			Nonresponders at week 24 (𝑛=14)
		Liver HCV RNA		Serum HCV RNA	Liver HCV RNA		Serum HCV RNA
		+Strand	−Strand		+Strand	−Strand
TLR3 mRNA	𝑟	0.149	0.173	0.100	0.407	0.442	0.066
	𝑃	0.469	0.398	0.626	0.149	0.114	0.823
RIG-I mRNA	𝑟	0.217	0.324	−0.070	0.797	0.744	0.513
	𝑃	0.288	0.107	0.735	<0.001	0.002	0.060
TRIF mRNA	𝑟	0.014	0.091	−0.254	0.659	0.620	0.280
	𝑃	0.946	0.659	0.211	0.010	0.018	0.333
IPS-1 mRNA	𝑟	0.012	0.100	−0.217	0.563	0.538	0.209
	𝑃	0.952	0.627	0.288	0.036	0.047	0.473
IRF3 mRNA	𝑟	0.023	−0.005	−0.312	0.647	0.521	0.189
	𝑃	0.911	0.981	0.121	0.012	0.056	0.517
IFN-β mRNA	𝑟	−0.154	−0.222	−0.174	0.433	0.411	−0.022
	𝑃	0.453	0.275	0.394	0.122	0.144	0.940