Clinical Study
Involvement of Differential Relationship between HCV Replication and Hepatic PRR Signaling Gene Expression in Responsiveness to IFN-Based Therapy
Table 2
Correlations between HCV replication (liver positive- and negative-strand HCV RNAs and circulating HCV RNA) and hepatic PRR signaling gene expression regarding virologic response at week 24.
| Hepatic gene expression | | Responders at week 24 () | Nonresponders at week 24 () | | Liver HCV RNA | Serum HCV RNA | Liver HCV RNA | Serum HCV RNA | | +Strand | −Strand | +Strand | −Strand |
| TLR3 mRNA | | 0.149 | 0.173 | 0.100 | 0.407 | 0.442 | 0.066 | | 0.469 | 0.398 | 0.626 | 0.149 | 0.114 | 0.823 | RIG-I mRNA | | 0.217 | 0.324 | | 0.797 | 0.744 | 0.513 | | 0.288 | 0.107 | 0.735 | <0.001 | 0.002 | 0.060 | TRIF mRNA | | 0.014 | 0.091 | | 0.659 | 0.620 | 0.280 | | 0.946 | 0.659 | 0.211 | 0.010 | 0.018 | 0.333 | IPS-1 mRNA | | 0.012 | 0.100 | | 0.563 | 0.538 | 0.209 | | 0.952 | 0.627 | 0.288 | 0.036 | 0.047 | 0.473 | IRF3 mRNA | | 0.023 | | | 0.647 | 0.521 | 0.189 | | 0.911 | 0.981 | 0.121 | 0.012 | 0.056 | 0.517 | IFN-β mRNA | | | | | 0.433 | 0.411 | | | 0.453 | 0.275 | 0.394 | 0.122 | 0.144 | 0.940 |
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