Clinical Study
Involvement of Differential Relationship between HCV Replication and Hepatic PRR Signaling Gene Expression in Responsiveness to IFN-Based Therapy
Table 3
Correlations between HCV replication (liver positive- and negative-strand HCV RNAs and circulating HCV RNA) and hepatic PRR signaling gene expression regarding posttreatment virologic response.
| Hepatic gene expression | | Patients with SVR () | Patients without SVR () | | Liver HCV RNA | Serum HCV RNA | Liver HCV RNA | Serum HCV RNA | | +Strand | −Strand | +Strand | −Strand |
| TLR3 mRNA | | 0.021 | 0.132 | 0.068 | 0.632 | 0.632 | 0.214 | | 0.925 | 0.557 | 0.763 | 0.009 | 0.009 | 0.427 | RIG-I mRNA | | 0.192 | 0.243 | | 0.760 | 0.693 | 0.511 | | 0.392 | 0.277 | 0.432 | <0.001 | 0.003 | 0.043 | TRIF mRNA | | 0.109 | 0.200 | | 0.465 | 0.485 | | | 0.631 | 0.373 | 0.339 | 0.069 | 0.057 | 0.914 | IPS-1 mRNA | | 0.072 | 0.131 | | 0.389 | 0.365 | 0.159 | | 0.750 | 0.562 | 0.243 | 0.137 | 0.165 | 0.556 | IRF3 mRNA | | 0.056 | 0.023 | | 0.545 | 0.426 | 0.175 | | 0.803 | 0.918 | 0.081 | 0.029 | 0.099 | 0.516 | IFN-β mRNA | | 0.034 | | −0.107 | 0.158 | 0.112 | | | 0.882 | 0.730 | 0.634 | 0.560 | 0.680 | 0.318 |
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