Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model: Implications for Newborn and Maternal Health

Table 3

Average pharmacokinetic parameters for human IgG (50 IU/kg dose) in the pregnant guinea pigs and the nonpregnant controls.

	AUC^b; (𝜇g*hr/mL)	CL^c; (mL/hr per kg)	Half-life (hours)
Pregnant, mean (STDEV)^a	1819 (501)	1.396 (0.381)	59 (25)*
Nonpregnant, mean (STDEV)	2770 (846)	0.916 (0.245)	95 (4)*

^∗𝑃<0.05.
^aOne pregnant guinea pig was excluded from analysis due to abnormally high AUC (4-5 times higher than the other sows).
^bArea under the curve.
^cClearance.