Research Article
BV associated bacteria specifically BVAB 1 and BVAB 3 as biomarkers for HPV risk and progression of cervical neoplasia
Table 2
Population characteristics and the association of BV associated bacteria in participants co-infected with HPV at enrolment.
| | HPV Negative (N =82) | HPV Positive (N =108) | p-value | Overall (N =190) |
| | A. vaginae | | | p <0.001 | | | Negative | 39 (47.6%) | 10 (9.3%) | | 49 (25.8%) | | Positive | 43 (52.4%) | 98 (90.7%) | | 141 (74.2%) | | BVAB 1 | | | p <0.001 | | | Negative | 30 (36.6%) | 11 (10.2%) | | 41 (21.6%) | | Positive | 52 (63.4%) | 97 (89.8%) | | 149 (78.4%) | | BVAB 2 | | | p =0.428 | | | Negative | 51 (62.2%) | 61 (56.5%) | | 112 (58.9%) | | Positive | 31 (37.8%) | 47 (43.5%) | | 78 (41.1%) | | BVAB 3 | | | p <0.001 | | | Negative | 51 (62.2%) | 38 (35.2%) | | 89 (46.8%) | | Positive | 31 (37.8%) | 70 (64.8%) | | 101 (53.2%) | | Lactobacillus spp | | | p =0.016 | | | Negative | 22 (26.8%) | 14 (13.0%) | | 36 (18.9%) | | Positive | 60 (73.2%) | 94 (87.0%) | | 154 (81.1%) | | Prevotella spp | | | p =0.238 | | | Negative | 1 (1.2%) | 5 (4.6%) | | 6 (3.2%) | | Positive | 81 (98.8%) | 103 (95.4%) | | 184 (96.8%) | | S. sanguinegens | | | p =0.007 | | | Negative | 34 (41.5%) | 25 (23.1%) | | 59 (31.1%) | | Positive | 48 (58.5%) | 83 (76.9%) | | 131 (68.9%) | | Age | | | p =0.392 | | | Mean ± SD(CV%) | 39.4 ± 8.17(20.7) | 40.3 ± 8.42(20.9) | | 39.9 ± 8.31(20.8) | | Median(Q1-Q3) | 39.0(33.0-45.0) | 42.0(33.0-46.0) | | 40.5(33.0-46.0) | | Min-Max | 25.0-54.0 | 25.0-54.0 | | 25.0-54.0 | | Gravida | | | p =0.533 | | | 0 | 5 (6.1%) | 7 (6.5%) | | 12 (6.3%) | | 1 | 19 (23.2%) | 38 (35.2%) | | 57 (30.0%) | | 2 | 25 (30.5%) | 31 (28.7%) | | 56 (29.5%) | | 3 | 16 (19.5%) | 16 (14.8%) | | 32 (16.8%) | | 4 | 10 (12.2%) | 8 (7.4%) | | 18 (9.5%) | | 5+ | 7 (8.5%) | 8 (7.4%) | | 15 (7.9%) | | No of lifetime sexual partners | | | p =0.314 | | | Mean ± SD(CV%) | 3.00 ± 1.36(45.2) | 3.57 ± 2.32(65.1) | | 3.35 ± 2.02(60.2) | | Median(Q1-Q3) | 3.00(2.00-4.00) | 3.00(2.00-5.00) | | 3.00(2.00-4.00) | | Min-Max | 1.00-6.00 | 1.00-10.0 | | 1.00-10.0 | | No of sex partners in past 12 months | | | p =0.804 | | | Mean ± SD(CV%) | 0.859 ± 0.418(48.7) | 0.883 ± 0.676(76.5) | | 0.873 ± 0.578(66.2) | | Median(Q1-Q3) | 1.00(1.00-1.00) | 1.00(1.00-1.00) | | 1.00(1.00-1.00) | | Min-Max | 0-2.00 | 0-6.00 | | 0-6.00 | | Having a regular partner | | | p =0.211 | | | No | 24 (29.3%) | 41 (38.0%) | | 65 (34.2%) | | Yes | 58 (70.7%) | 67 (62.0%) | | 125 (65.8%) | | Time on ART(years) | | | p =0.317 | | | Mean ± SD(CV%) | 7.24 ± 4.78(66.0) | 6.59 ± 4.86(73.7) | | 6.88 ± 4.82(70.1) | | Median(Q1-Q3) | 6.00(4.00-11.0) | 5.50(2.00-10.0) | | 6.00(3.00-10.0) | | Min-Max | 0-24.0 | 0-18.0 | | 0-24.0 | | No of years since HIV diagnosis | | | p =0.530 | | | Mean ± SD(CV%) | 8.30 ± 5.27(63.5) | 7.79 ± 5.52(70.9) | | 8.01 ± 5.41(67.5) | | Median(Q1-Q3) | 8.00(4.00-12.0) | 8.00(2.75-12.0) | | 8.00(3.00-12.0) | | Min-Max | 0-26.0 | 0-23.0 | | 0-26.0 |
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