Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations

Table 3

Analytical parameters for fixed time method of the kinetic spectrophotometric parameter for determination of investigated cephalosporins.

Reaction time	Linear range (𝜇g mL^-1)	Intercept (𝑎)	Standard deviation of intercept(𝑆𝑎)	Slope (𝑏)	Standard deviation of slope (𝑆𝑏)	Correlation coefficient (𝑟)	LOD (𝜇g mL^-1)
Cefotaxime
3	5–25	0.00568	0.005827	0.02845	0.0003607	0.9993	0.6144
6	5–19	0.01698	0.005317	0.03472	0.0004140	0.9996	0.4590
9	5–17	0.02618	0.005363	0.04004	0.0004582	0.9997	0.4018
12	5–17	0.02880	0.005112	0.04516	0.0004368	0.9998	0.3395
15	5–17	0.01995	0.005112	0.05102	0.0004368	0.9998	0.3005
Cephapirin
3	5–25	0.00105	0.005027	0.02801	0.0003088	0.9995	0.5384
6	5–19	0.03286	0.004621	0.03176	0.0003598	0.9996	0.4364
9	5–17	0.05639	0.003562	0.03525	0.0003043	0.9998	0.30314
12	5–17	0.08327	0.003653	0.03791	0.0003121	0.9998	0.289
15	5–17	0.09054	0.003790	0.04196	0.0003238	0.9999	0.27097
Cephradine
3	5–25	0.01464	0.009607	0.03216	0.0005901	0.9985	0.896
6	5–19	0.02004	0.007665	.03856	0.0005967	0.9993	0.596
9	5–17	0.04891	0.005234	0.04184	0.0004471	0.9997	0.375
12	5–17	0.06645	0.004959	0.04566	0.0004237	0.9998	0.3258
15	5–17	0.07721	0.005174	0.04907	0.0004420	0.9998	0.3163
Cephalexin
3	5–25	0.01573	0.006484	0.03518	0.0003983	0.9994	0.5529
6	5–19	−0.0067	0.007189	0.04353	0.0005580	0.9995	0.495
9	5–17	−0.0012	0.005694	0.04841	0.0004865	0.9997	0.3528
12	5–17	−0.0040	0.005204	0.05354	0.0004446	0.9998	0.2915
15	5–17	−0.0015	0.005412	0.05821	0.0004624	0.9998	0.2789
Ceftazidime
3	5–25	−0.0029	0.003859	0.01905	0.0002371	0.9993	0.6077
6	5–19	0.03039	0.004045	0.02324	0.0003149	0.9994	0.52216
9	5–17	0.04486	0.003966	0.02871	0.0003388	0.9997	0.41442
12	5–17	0.06577	0.003875	0.03270	0.0003311	0.9997	0.3555
15	5–17	0.07993	0.003785	0.03636	0.0003234	0.9998	0.3128
Cefazoline
3	5–25	0.00027	0.006894	0.02935	0.0004235	0.9991	0.70466
6	5–19	0.02604	0.006741	0.03439	0.0005246	0.9993	0.588
9	5–17	0.03064	0.006040	0.04064	0.0005161	0.9996	0.4458
12	5–17	0.04073	0.005576	0.04566	0.0004764	0.9997	0.366
15	5–17	0.03973	0.005958	0.05038	0.0005090	0.9997	0.3547
Ceftriaxone
3	5–25	−0.0024	0.004203	0.02274	0.0002582	0.9994	0.55448
6	5–19	0.02739	0.004303	0.02770	0.0003329	0.9996	0.466
9	5–17	0.01350	0.004163	0.03307	0.0003557	0.9997	0.377
12	5–17	0.02534	0.004423	0.03741	0.0003779	0.9997	0.3546
15	5–17	0.03982	0.003818	0.03939	0.0003262	0.9998	0.2907
Cefuroxime
3	5–25	−0.0065	0.005980	0.02629	0.0003674	0.9991	0.68238
6	5–19	0.02696	0.005472	0.02994	0.00004260	0.9994	0.54829
9	5–17	0.04286	0.005334	0.03471	0.0004557	0.9996	0.4610
12	5–17	0.05480	0.004229	0.03845	0.0003613	0.9998	0.32996
15	5–17	0.06130	0.005614	0.04266	0.0004796	0.9997	0.2747