Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

Figure 1

Chemical structures of studied compounds. (a) Naratriptan (Nara). (b) Zolmitriptan (Zol). (c) Pizotifen malate (Pizo). (d) Dihydroergotamine mesilate (DHE). (e) Ketotifen fumarate (Keto).

(a)

(b)

(c)

(d)

(e)