Research Article
Formulation and development of Serratiopeptidase enteric coated tablets and analytical method validation by UV Spectroscopy
Table 1
Composition of formulated tablets.
| S. No. | Materials (mg/tablet) | F1 | F2 | F3 | F4 | F5 |
| 1. | Serratiopeptidase | 10.50 | 10.50 | 10.50 | 10.50 | 10.50 | 2. | MCCP pH 101 | 141.00 | — | — | — | — | 3. | MCCP pH 102 | — | 139.50 | 132.50 | 132.50 | 132.50 | 4. | Colloidal silicon dioxide | 2.00 | 2.50 | 4.00 | 4.00 | 4.00 | 5. | Sodium starch glycolate | 3.50 | 4.50 | 5.50 | 5.50 | 5.50 | 6. | Crospovidone | — | — | 4.00 | 4.00 | 4.00 | 7. | Magnesium stearate | 1.50 | 1.50 | 2.00 | 2.00 | 2.00 | 8. | Stearic acid | 1.50 | 1.50 | 1.50 | 1.50 | 1.50 | Total weight (uncoated) | 160.00 | 160.00 | 160.00 | 160.00 | 160.00 |
| Seal coating materials | 1. | White shellac | — | — | 5.10 | 5.70 | 6.37 | 2. | Castor oil | — | — | 0.062 | 0.062 | 0.062 | 3. | Isopropyl alcohol | — | — | 105.00 | 105.00 | 105.00 |
| Enteric coating materials | 1. | HPMC phthalate 40 | — | — | 8.00 | 8.00 | 13.44 | 2. | Ethyl cellulose | — | — | 2.74 | 2.74 | 3.820 | 3. | Castor oil | — | — | 0.47 | 0.47 | 0.97 | 4. | Titanium dioxide | — | — | 0.55 | 0.55 | 0.55 | 5. | Lake Erythrosine | — | — | 0.11 | 0.11 | 0.11 | 6. | Isopropyl alcohol | — | — | 85.00 | 85.00 | 85.00 | 7. | Methylene chloride | — | — | 150.00 | 150.00 | 150.00 | Targeted weight in mg (coated) | — | — | 170.00 | 170.00 | 170.00 |
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