Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques

Table 2

Data of the accuracy tests of IND and NCT for the proposed methods.

Concentration (μg/mL)	IND mean recovery ± RSD %			NCT mean recovery ± RSD %
Method	ZCD2	DWD1	SS	ZCD2	DWD1	RS
5	99.06 ± 0.62	101.71 ± 0.45	99.44 ± 1.78	99.13 ± 1.75	100.15 ± 1.34	99.58 ± 1.41
10	98.79 ± 0.48	100.06 ± 1.44	99.44 ± 0.51	99.92 ± 0.26	99.21 ± 0.75	99.25 ± 1.14
15	99.93 ± 1.75	100.81 ± 1.11	101.59 ± 1.27	99.16 ± 1.53	98.20 ± 0.38	100.46 ± 0.49
20	100.35 ± 0.96	100.22 ± 0.98	100.09 ± 1.01	100.66 ± 0.62	100.46 ± 0.23	100.55 ± 1.52
25	99.78 ± 1.94	100.09 ± 1.66	99.99 ± 0.51	98.48 ± 1.87	100.44 ± 1.30	99.27 ± 0.34
30	99.70 ± 1.88	99.18 ± 0.81	98.98 ± 1.20	100.97 ± 0.55	100.71 ± 0.76	100.13 ± 0.81
Mean recovery ± RSD %	99.60 ± 1.94	100.35 ± 1.25	99.92 ± 1.28	99.72 ± 1.40	99.86 ± 1.17	99.87 ± 1.04

Three repetitions of each concentration were analyzed with nine total repetitions. All 18 repetitions of each wavelength.