Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques
Table 6
Data of the analysis of IND and NCT in the dosage formulations with the proposed methods.
Dosage formulation + (IND : NCT) ratio
IND mean recovery ± RSD %
NCT mean recovery ± RSD %
Method
ZCD2
DWD1
SS
ZCD2
DWD1
RS
IR1 mg (1 : 3)
100.42 ± 0.43
100.57 ± 0.72
101.02 ± 0.61
99.52 ± 1.46
100.92 ± 0.61
100.83 ± 0.38
IR (1 : 1)
101.28 ± 0.33
101.17 ± 0.64
101.14 ± 1.21
101.27 ± 0.34
99.45 ± 1.18
99.79 ± 0.34
IR (1 : 0.33)
101.36 ± 0.37
101.82 ± 0.59
99.98 ± 0.47
101.37 ± 1.18
100.62 ± 1.83
99.58 ± 1.14
IR mean recovery ± RSD %
101.02 ± 0.55
101.19 ± 0.78
100.71 ± 0.90
100.72 ± 1.30
100.33 ± 1.31
100.06 ± 0.85
SR2 (1 : 1)
98.63 ± 0.54
99.00 ± 0.50
99.16 ± 1.51
99.59 ± 1.44
99.91 ± 0.48
100.44 ± 0.65
SR (1 : 0.33)
99.63 ± 0.90
99.74 ± 0.48
99.51 ± 0.57
101.26 ± 0.95
101.62 ± 0.34
98.90 ± 0.71
SR (1 : 0.17)
98.62 ± 0.87
103.73 ± 0.34
98.63 ± 0.66
101.53 ± 0.89
104.53 ± 0.77
96.79 ± 0.97
SR mean recovery ± RSD %
98.96 ± 0.85
100.82 ± 2.22
99.10 ± 0.95
100.79 ± 1.32
102.02 ± 2.04
98.71 ± 1.75
1IR contains 50 mg of IND as labeled. 2SR contains 75 mg of IND as labeled. Three repetitions of each ratio.