Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques

Table 6

Data of the analysis of IND and NCT in the dosage formulations with the proposed methods.

Dosage formulation + (IND : NCT) ratio	IND mean recovery ± RSD %			NCT mean recovery ± RSD %
Method	ZCD2	DWD1	SS	ZCD2	DWD1	RS
IR^1 mg (1 : 3)	100.42 ± 0.43	100.57 ± 0.72	101.02 ± 0.61	99.52 ± 1.46	100.92 ± 0.61	100.83 ± 0.38
IR (1 : 1)	101.28 ± 0.33	101.17 ± 0.64	101.14 ± 1.21	101.27 ± 0.34	99.45 ± 1.18	99.79 ± 0.34
IR (1 : 0.33)	101.36 ± 0.37	101.82 ± 0.59	99.98 ± 0.47	101.37 ± 1.18	100.62 ± 1.83	99.58 ± 1.14
IR mean recovery ± RSD %	101.02 ± 0.55	101.19 ± 0.78	100.71 ± 0.90	100.72 ± 1.30	100.33 ± 1.31	100.06 ± 0.85
SR^2 (1 : 1)	98.63 ± 0.54	99.00 ± 0.50	99.16 ± 1.51	99.59 ± 1.44	99.91 ± 0.48	100.44 ± 0.65
SR (1 : 0.33)	99.63 ± 0.90	99.74 ± 0.48	99.51 ± 0.57	101.26 ± 0.95	101.62 ± 0.34	98.90 ± 0.71
SR (1 : 0.17)	98.62 ± 0.87	103.73 ± 0.34	98.63 ± 0.66	101.53 ± 0.89	104.53 ± 0.77	96.79 ± 0.97
SR mean recovery ± RSD %	98.96 ± 0.85	100.82 ± 2.22	99.10 ± 0.95	100.79 ± 1.32	102.02 ± 2.04	98.71 ± 1.75

¹IR contains 50 mg of IND as labeled. ²SR contains 75 mg of IND as labeled. Three repetitions of each ratio.