A Simple and Rapid LC-MS/MS Method for the Quantification of Nirmatrelvir/Ritonavir in Plasma of Patients with COVID-19

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Analytes</td><td class="align_center">MRM transition <i>m</i>/<i>z</i> (<i>Q</i>1⟶<i>Q</i>3)</td><td class="align_center">Fragmentor (<i>V</i>)</td><td class="align_center">CE (eV)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Nirmatrelvir</td><td class="align_center">500.2⟶110.1</td><td class="align_center">125</td><td class="align_center">18</td></tr><tr><td class="align_left">Ritonavir</td><td class="align_center">721.3⟶296.1</td><td class="align_center">140</td><td class="align_center">17</td></tr><tr><td class="align_left">Selinexor (IS)</td><td class="align_center">444.1⟶282.0</td><td class="align_center">120</td><td class="align_center">19</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Mass spectrometry parameters of analytes and IS.</div>

International Journal of Analytical Chemistry

tab1

Table 1

Table 1: A Simple and Rapid LC-MS/MS Method for the Quantification of Nirmatrelvir/Ritonavir in Plasma of Patients with COVID-19 