Research Article
A Simple and Rapid LC-MS/MS Method for the Quantification of Nirmatrelvir/Ritonavir in Plasma of Patients with COVID-19
Table 3
Inter- and intraday precision and accuracy of analytes (n = 5).
| Analytes | Nominal concentration (ng/mL) | Interday measured concentration (ng/mL) ± SD | RSD (%) | RE (%) | Intraday measured concentration (ng/mL) ± SD | RSD (%) | RE (%) |
| Nirmatrelvir | 5 | 4.8 ± 0.4 | 7.9 | −3.9 | 5.0 ± 2.2 | 9.9 | 0.1 | 1000 | 983.3 ± 89.1 | 9.1 | −1.7 | 982.3 ± 78.0 | 7.9 | −1.8 | 2000 | 2050 ± 105.6 | 5.2 | 2.5 | 2088 ± 104.4 | 5.0 | 4.4 |
| Ritonavir | 5 | 4.8 ± 0.7 | 13.6 | 4.1 | 5.1 ± 0.7 | 13.4 | 1.5 | 1000 | 1031 ± 118.7 | 11.5 | 3.1 | 1078 ± 18.1 | 1.7 | 7.8 | 2000 | 2088 ± 100.4 | 4.8 | 4.4 | 1998 ± 16.2 | 0.8 | −0.1 |
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