Analytical and Clinical Evaluation of a Chemiluminescent Immunoassay to Detect Serum Chitinase-3-like Protein 1 in HBV-Related Liver Diseases

Table 5

Comparison of serum CHI3L1 and clinical indicators.

Indicators	CHI3L1	ALT	AST	ALP	GGT	TP	TBIL	AFP	LDH	FIB-4	APRI
Diagnostic value
AUC (HCC)	0.808	0.507	0.748	0.698	0.723	0.614	0.522	0.836	0.767	0.884	0.821
AUC (LC)	0.686	0.510	0.589	0.570	0.587	0.552	0.566	0.600	0.516	0.758	0.731
Correlation analysis
r (CH I3L1)	—	0.032	0.284	0.374	0.074	0.049	0.007	0.694	0.431	0.638	0.543
	—	0.752	0.005	0.001	0.470	0.630	0.949	0.001	0.001	0.001	0.001

CHI3L1, chitinase-3-like protein 1; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP, alkaline phosphatase; GGT, glutamyl endopeptidase; TP, total protein; TBIL, total bile acid; AFP, α-fetoprotein; LDH, lactate dehydrogenase; FIB-4, fibrosis-4; APRI, aspartate aminotransferase-to-platelet ratio index; AUC, the area under the receiver operating characteristic curve; HCC, hepatic carcinoma; LC, liver cirrhosis.