Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS

Table 2

Main pharmacokinetic parameters after intragastric (5 mg/kg) and intravenous (1 mg/kg) administration of ziyuglycoside I and ziyuglycoside II in rats.

Compound	Group	AUC(0-t)	AUC(0-∞)		CLz/F
		ng/mL  h	ng/mL  h	h	L/h/kg	L/kg	ng/mL
Ziyuglycoside I	ig	95.4 ± 7.2	109.0 ± 11.8	5.1 ± 2.5	46.3 ± 5.2	329.2 ± 143.6	36.6 ± 5.8
	iv	834.7 ± 249.2	838.3 ± 250.3	1.8 ± 0.7	1.3 ± 0.3	3.5 ± 2.0	1268.0 ± 344.8
Ziyuglycoside II	ig	438.9 ± 42.4	458.3 ± 46.3	4.9 ± 1.5	11.0 ± 1.0	77.3 ± 22.5	102.2 ± 14.5
	iv	1933.2 ± 209.1	1979.2 ± 185.7	6.2 ± 3.1	0.5	4.6 ± 2.4	1374.3 ± 224.5