Research Article
CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer’s Dementia Spectrum
Table 4
Linear regression between cognitive assessments and targeted proteomics.
| | CN | MCI | AD | square | Beta coefficient | value | square | Beta coefficient | value | square | Beta coefficient | value |
| CDR | IASNTQSR | 0.014 | 0.095 | 0.197 | 0.029 | 0.170 | 0.002 | 0.004 | 0.013 | 0.898 | VAELEDEK | 0.007 | -0.033 | 0.629 | 0.017 | -0.122 | 0.023 | 0.013 | -0.095 | 0.321 | VVSSIEQK | 0.006 | 0.012 | 0.867 | 0.019 | 0.129 | 0.016 | 0.024 | 0.142 | 0.141 | GDSVVYGLR | 0.013 | 0.087 | 0.199 | 0.007 | 0.057 | 0.274 | 0.006 | 0.042 | 0.660 | EPVAGDAVPGPK | 0.008 | 0.046 | 0.495 | 0.006 | -0.051 | 0.333 | 0.011 | -0.084 | 0.385 | QETLPSK | 0.015 | 0.093 | 0.168 | 0.008 | 0.068 | 0.190 | 0.006 | -0.041 | 0.676 | ADAS-11 | IASNTQSR | 0.145 | -0.091 | 0.183 | 0.093 | 0.142 | 0.007 | 0.017 | 0.115 | 0.271 | VAELEDEK | 0.160 | -0.148 | 0.018 | 0.097 | -0.156 | 0.002 | 0.013 | -0.084 | 0.383 | VVSSIEQK | 0.146 | -0.093 | 0.157 | 0.106 | 0.184 | <0.001 | 0.090 | 0.294 | 0.002 | GDSVVYGLR | 0.145 | -0.085 | 0.179 | 0.076 | 0.035 | 0.481 | 0.013 | 0.084 | 0.379 | EPVAGDAVPGPK | 0.162 | -0.154 | 0.014 | 0.083 | -0.094 | 0.064 | 0.014 | -0.092 | 0.345 | QETLPSK | 0.143 | -0.066 | 0.296 | 0.079 | 0.069 | 0.165 | 0.009 | 0.058 | 0.549 | ADAS-13 | IASNTQSR | 0.177 | -0.082 | 0.221 | 0.129 | 0.176 | 0.001 | 0.019 | 0.145 | 0.166 | VAELEDEK | 0.195 | -0.156 | 0.011 | 0.126 | -0.165 | 0.001 | 0.004 | -0.055 | 0.564 | VVSSIEQK | 0.172 | -0.037 | 0.565 | 0.149 | 0.238 | <0.001 | 0.076 | 0.278 | 0.004 | GDSVVYGLR | 0.175 | -0.064 | 0.298 | 0.106 | 0.069 | 0.161 | 0.008 | 0.085 | 0.375 | EPVAGDAVPGPK | 0.192 | -0.146 | 0.017 | 0.108 | -0.086 | 0.083 | 0.005 | -0.066 | 0.496 | QETLPSK | 0.174 | -0.057 | 0.360 | 0.109 | 0.092 | 0.060 | 0.006 | 0.070 | 0.472 | MMSE | IASNTQSR | 0.034 | -0.141 | 0.053 | 0.065 | -0.102 | 0.053 | 0.008 | 0.000 | 0.998 | VAELEDEK | 0.018 | -0.021 | 0.757 | 0.059 | 0.063 | 0.226 | 0.023 | 0.122 | 0.202 | VVSSIEQK | 0.018 | -0.017 | 0.807 | 0.078 | -0.157 | 0.002 | 0.023 | -0.126 | 0.192 | GDSVVYGLR | 0.026 | 0.093 | 0.165 | 0.066 | -0.102 | 0.043 | 0.010 | 0.049 | 0.606 | EPVAGDAVPGPK | 0.017 | 0.005 | 0.946 | 0.055 | -0.012 | 0.817 | 0.013 | 0.072 | 0.459 | QETLPSK | 0.022 | 0.065 | 0.333 | 0.071 | -0.127 | 0.012 | 0.010 | 0.042 | 0.662 |
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CN: cognitively normal; MCI: mild cognitive impairment; AD: Alzheimer’s disease. values < 0.05 are in bold. |