In Silico Investigation of Novel Compounds as Inhibitors of Acetylcholinesterase Enzyme for the Treatment of Alzheimer’s Diseases

Figure 2

(a) Surface mapping of donepezil in the binding pocket and none of the groups on the ring passing through the surface, which shows that there was favourable contact with the binding pocket. (b) The ligand interaction was with 6-ring PHE 331 and 6-ring TRP 279.

(a)

(b)