In Silico Investigation of Novel Compounds as Inhibitors of Acetylcholinesterase Enzyme for the Treatment of Alzheimer’s Diseases

Table 2

Druglikeness profile of compounds investigated.

S/no.	Initial of compound	MW g/mol	No. of rotatable bond	H-acceptor	H-donor	LogP	LogS	BBB	GI permeability
1	Donepezil	379.49	6	4	0	4.91	-4.81	Yes	High
2	Galantamine	287.35	1	4	1	2.03	-2.93	Yes	High
3	Zoladex	970.08	34	15	12	-2.11	1.47	No	Low
4	CHEMBL-1240685	1269.41	43	16	17	1.36	-4.06	No	Low