International Journal of Biomaterials
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Acceptance rate19%
Submission to final decision104 days
Acceptance to publication14 days
CiteScore4.400
Journal Citation Indicator0.400
Impact Factor3.1

Development of Intelligent Indicators Based on Cellulose and Prunus domestica Extracted Anthocyanins for Monitoring the Freshness of Packaged Chicken

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International Journal of Biomaterials publishes research on the theory, design, engineering, fabrication, and implementation of materials and devices for therapeutic or diagnostic use in biological systems.

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International Journal of Biomaterials maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

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Research Article

Improving Biocompatibility of Polyurethanes Apply in Medicine Using Oxygen Plasma and Its Negative Effect on Increased Bacterial Adhesion

Polyurethanes (PUs) are versatile polymers used in medical applications due to their high flexibility and fatigue resistance. PUs are widely used for synthetic blood vessels, wound dressings, cannulas, and urinary and cardiovascular catheters. Many scientific reports indicate that surface wettability is crucial for biocompatibility and bacterial adhesion. The use of oxygen plasma to modify PUs is advantageous because of its effectiveness in introducing oxygen-containing functional groups, thereby altering surface wettability. The purpose of this study was to investigate the effect of the modification of the oxygen plasma of polyurethane on its biocompatibility with lung tissue (A549 cell line) and the adhesion of Gram-positive bacteria (S. aureus and S. epidermidis). The results showed that the modification of polyurethane by oxygen plasma allowed the introduction of functional groups containing oxygen (-OH and -COOH), which significantly increased its hydrophilicity (change from 105° ± 2° to 9° ± 2°) of PUs. Surface analysis by atomic force microscopy (AFM) showed changes in PU topography (change in maximum height from ∼110.3 nm to ∼32.1 nm). Moreover, biocompatibility studies on A549 cells showed that on the PU-modified surface, the cells exhibited altered morphology (increases in cell surface area and length, and thus reduced circularity) without concomitant effects on cell viability. However, serial dilution and plate count and microscopic methods confirmed that plasma modification significantly increased the adhesion of S. aureus and S. epidermidis bacteria. This study indicate the important role of surface hydrophilicity in biocompatibility and bacterial adhesion, which is important in the design of new medical biomaterials.

Review Article

Current Strategies for Tracheal Decellularization: A Systematic Review

The process of decellularization is crucial for producing a substitute for the absent tracheal segment, and the choice of agents and methods significantly influences the outcomes. This paper aims to systematically review the efficacy of diverse tracheal decellularization agents and methods using the PRISMA flowchart. Inclusion criteria encompassed experimental studies published between 2018 and 2023, written in English, and detailing outcomes related to histopathological anatomy, DNA quantification, ECM evaluation, and biomechanical characteristics. Exclusion criteria involved studies related to 3D printing, biomaterials, and partial decellularization. A comprehensive search on PubMed, NCBI, and ScienceDirect yielded 17 relevant literatures. The integration of various agents and methods has proven effective in the process of tracheal decellularization, highlighting the distinct advantages and drawbacks associated with each agent and method.

Research Article

Graphene Quantum Dots: Green Synthesis, Characterization, and Antioxidant and Antimicrobial Potential

Antibiotic resistance is becoming more common, emphasising the demand for novel antibacterial treatments. The current investigation describes the green synthesis of graphene quantum dots (GQDs) using M. indica leaves and characterization via Fourier-transform infrared spectra (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and ultraviolet-visible (UV-Vis) spectrophotometer. The results showed that GQDs are spherical in shape. In vitro antioxidant and antimicrobial studies indicate that the biological efficacy of synthesized GQDs was higher than the ethanolic leaf extract. GQDs exhibited the highest scavenging efficacy with lowest IC50 (half-maximal inhibitory concentration) value. However, antimicrobial study showed more inhibitory activity of GQDs against all screened microorganisms, i.e., Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa, and fungi, i.e., Aspergillus niger and Aspergillus flavus. Graphene quantum dots facilitate reactive oxygen species (ROS) which ultimately lead to antioxidant and antibacterial activity. This approach would provide an efficient alternate method for tackling microorganisms.

Research Article

Investigation of Roughness, Morphology, and Wettability Characteristics of Biopolymer Composite Coating on SS 316L for Biomedical Applications

This project aims to create a 316L stainless steel coated with a biocomposite based on chitosan for use in the biomedical industry. To completely coat the material, the dip-coating technique was used to apply plain chitosan, chitosan nanosilver, chitosan biotin, and chitosan-nanosilver-biotin in that order. This coating’s surface morphology was investigated with field emission scanning electron microscopy (FESEM). Surface roughness, average size distribution, and 2D and 3D surface tomography were all investigated using scanning probe microscopy and atomic force microscopy (SPM and AFM). The Fourier transform infrared (FTIR) spectroscopy technique was used to quantify changes in functional groups. To evaluate the coated samples’ wettability, contact angle measurements were also performed. The chitosan (CS) + nanosilver, CS + biotin, and CS + biotin + nanosilver-coated 316L stainless steel showed roughness values of about 8.68, 4.21, and 3.3 nm, respectively, compared with the neat chitosan coating, which exhibits 12 nm roughness, indicating a strong effect of biotin and nanosilver on surface topography whereas the coating layers were homogenous, measuring around 33 nm in thickness. For CS + nanosilver and CS + biotin, the average size of agglomerates was approximately 444 nm and 355 nm, respectively. The coatings showed adequate wettability for biomedical applications, were homogeneous, and had no cracks. Their contact angles were around 51–75 degrees. All of these results point to the composite coating’s intriguing potential for use in biological applications.

Research Article

Synergistic Effects of SDS and H2O2 Combinations on Tracheal Scaffold Development: An In Vitro Study Using Goat Trachea

Currently, a tissue-engineered trachea has been popularly used as a biological graft for tracheal replacement in severe respiratory diseases. In the development of tissue-engineered tracheal scaffolds, in vitro studies play a crucial role in allowing researchers to evaluate the efficacy and safety of scaffold designs and fabrication techniques before progressing to in vivo or clinical trials. This research involved the decellularization of goat trachea using SDS, H2O2, and their combinations. Various quantitative and qualitative assessments were performed, including histological analysis, immunohistochemistry, and biomechanical testing. Hematoxylin and eosin staining evaluated the cellular content, while safranin O-fast green and Masson’s trichrome staining assessed glycosaminoglycan content and collagen distribution, respectively. The immunohistochemical analysis focused on detecting MHC-1 antigen presence. Tensile strength measurements were conducted to evaluate the biomechanical properties of the decellularized scaffolds. The results demonstrated that the combination of SDS and H2O2 for goat tracheal decellularization yielded scaffolds with minimal cellular remnants, low toxicity, preserved ECM, and high tensile strength and elasticity. This method holds promise for developing functional tracheal scaffolds to address severe respiratory diseases effectively.

Research Article

Development and Evaluation of an Eco-Friendly Hand Sanitizer Formulation Valorized from Fruit Peels

Hand sanitizer usage has proven to be a common and practical method for reducing the spread of infectious diseases which can be caused by many harmful pathogens. There is a need for alcohol-free hand sanitizers because most hand sanitizers on the market are alcohol-based, and regular use of them can damage the skin and can be hazardous. India is the world’s largest producer of fruits and one of the major problems after fruit consumption is their peels, causing waste management problems and contributing to the formation of greenhouse gases leading to air pollution and adding to the problem of climate change. Valorization of such wastes into other value-added products and their incorporation into formulations of eco-friendly alcohol-free hand sanitizers would solve these issues, save the environment, benefit the society, and help in achieving the sustainable development goals. Thus, this research focuses on formulating an effective natural alcohol-free hand sanitizer that harnesses the antimicrobial properties of the various types of bioactive components found in fruit peels of pomegranate, sweet lime, and lemon. The peel extracts and the formulated sanitizer proved considerable antimicrobial activity against the pathogenic Escherichia coli and hand microflora. Molecular docking was also applied to examine ligand-protein interaction patterns and predict binding conformers and affinity of the sanitizer phytocompounds towards target proteins in COVID-19, influenza, and pneumonia viruses. The binding affinities and the protein-ligand interactions virtual studies revealed that the sanitizer phytocompounds bind with the amino acids in the target proteins’ active sites via hydrogen bonding interactions. As a result, it is possible to formulate a natural, alcohol-free hand sanitizer from fruit peels that is effective against pathogenic germs and viruses using the basic structure of these potential findings.

International Journal of Biomaterials
 Journal metrics
See full report
Acceptance rate19%
Submission to final decision104 days
Acceptance to publication14 days
CiteScore4.400
Journal Citation Indicator0.400
Impact Factor3.1
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