International Journal of Cell Biology

Organelle Crosstalk in Apoptotic and Survival Pathways


Publishing date
06 Jul 2012
Status
Published
Submission deadline
03 Feb 2012

Lead Editor

1Dipartimento di Biologia, Universita' di Roma Tor Vergata, 00133 Rome, Italy

2Department of Histology and Embryology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland

3Department of Experimental and Diagnostic Medicine Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy

4Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland


Organelle Crosstalk in Apoptotic and Survival Pathways

Description

Cell damage as a result of pathological conditions or treatments with antitumor agents is perceived by intracellular sensors that activate complex networks of death and survival pathways, determining the fate of the damaged cell. The dissection of intracellular signals leading to apoptosis or survival has disclosed molecular functional connections between different organelles and supramolecular structures, including sequestration of pro- and antiapoptotic proteins, control of ionic fluxes, and propagation of elastic forces, revealing higher-order levels of control in the cell-autonomous life/death decision. The expectance from translational medicine of mechanisms, where to exert pharmacological control of deregulated apoptotic responses, recommends the integrated analysis of interorganellar coordination.

We invite authors to submit original research and review articles including traditional molecular studies and system biology approaches, which may help defining new paradigms in the control of apoptotic and survival responses by cell organelles, especially considering interorganellar crosstalks. Original papers providing novel technical approaches to organellar dynamics are welcome. Potential topics include, but are not limited to:

  • Organelles and cytoskeletal structures in the sequestration and liberation of pro- and antiapoptotic proteins
  • Lysosomes in apoptosis and their interactions with other organelles
  • Plasma membrane-mediated signals in apoptosis and survival
  • ER stress and the induction of the intrinsic and extrinsic apoptotic pathway
  • Relationship between morphological and biochemical alterations in apoptosis
  • ER crosstalk with mitochondria, nucleus, and plasma membrane in survival and apoptosis
  • Crosstalk between protease systems (e.g., caspase, calpain, cathepsin, and proteasome) in survival and cell death pathways
  • Control of apoptosis and survival by Bcl-2 family members trafficking
  • Role of the p53 family in organelle coordination in apoptosis
  • Cellular sensors of damage and propagation of survival or apoptotic signals
  • Role of organellar surface charge in apoptosis and survival pathways

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijcb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:

International Journal of Cell Biology
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Acceptance to publication27 days
CiteScore4.200
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