In the past few decades, extensive studies have been done to achieve progress in biotechnology and tissue engineering. However, in-depth research on the bioactive compounds of orchids is still limited to several species.

To address the lack of phytochemical knowledge, this Special Issue aims to review the latest developments and biosynthesis of various biomaterials for maxillofacial rehabilitation in dentistry by using the principles of biotechnology and tissue engineering by integrating the knowledge of various areas of biosynthetic machinery, pharmacognosy, biotechnology, and digital technologies. Dentistry is focusing on the rehabilitation of patients with compromised oral tissues, maxillary defects, mandibular defects, and oro-facial defects. The Special Issue also focuses on preclinical research, clinical studies, and concerns about treatment. As a secondary objective, the contributions to the collection will provide interesting concepts and ideas to research in the fields of oral biology, pathophysiology, biochemistry, and developmental biology.

Potential topics include but are not limited to the following:

• Developmental biology
• Biotechnology
• Dentistry
• Oral biology and pathophysiology
• Periodontology
• Oral surgery
• Biomaterials
• Dental biomaterials
• Maxillofacial rehabilitation