International Journal of Endocrinology / 2014 / Article / Tab 1 / Review Article
Testosterone Deficiency, Cardiac Health, and Older Men Table 1 Association of low testosterone levels with all-cause mortality by different cut-offs from recent studies.
Cut-off for the definition of low total testosterone (TT) MMAS; [8 ] TT < 6.94 nmol/L (200 ng/dL) Wang; [31 ] TT < 8.0 nmol/L (230 ng/dL) Rancho Bernardo; [7 ] TT < 8.36 nmol/L (241 ng/dL) Male veterans study; [32 ] TT < 8.7 nmol/L (250 ng/dL) HIM; [33 ] TT < 10.41 nmol/L (300 ng/dL) EPIC; [6 ] TT < 12.5 nmol/L (360 ng/dL) Age-specific cut-off <10th percentile Low TT (
) 34 69 82 98 241 474 Model 1 1.59 (0.83; 4.02) 1.96 (0.93; 3.63) 2.21 (1.26; 3.89)** 2.24 (1.41; 3.57)** 1.33 (0.93; 1.90) 1.28 (0.95; 1.72) 2.21 (1.40; 3.49)** Model 2 2.12 (1.01; 4.46)* 2.08 (1.12; 3.86)* 2.33 (1.33; 4.12)** 2.10 (1.34; 3.29)** 1.28 (0.89; 1.84) 1.20 (0.88; 1.62) 2.26 (1.43; 3.59)** Model 3 2.50 (1.18; 5.27)* 2.24 (1.21; 4.17)* 2.53 (1.43; 4.47)** 2.32 (1.38; 3.89)** 1.37 (0.95; 1.99) 1.28 (1.93; 1.75) 2.35 (1.47; 3.74)*** Model 4 2.68 (1.19; 6.04)* 2.13 (1.06; 4.26)* 2.56 (1.38; 4.76)** 1.92 (1.18; 3.14)** 1.11 (0.72; 1.69) 1.10 (0.78; 1.56) 2.25 (1.35; 3.75)**
Model 1: adjusted for age. Model 2: adjusted for age, and WC. Model 3: adjusted for model 2, smoking (3 categories), high-risk alcohol use, and physical activity. Model 4: adjusted for model 3, renal insufficiency, and DHEAS. HR: hazard ratio; CI: 95% confidence interval; CVD: cardiovascular disease; WC: waist circumference; DHEAS: dehydroepiandrosterone sulfate.
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