Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan
Table 4
Clinical and metabolic features between those with E/E genotype and K-containing allele among type 2 diabetic and nondiabetic subjects, respectively.
Type 2 diabetic subjects
Nondiabetic subjects
Genotypes
E/E ()
E/K + K/K ()
value*
E/E ()
E/K + K/K ()
value*
Sex (M : F)
4 : 2
16 : 16
0.663$
11 : 13
15 : 30
0.434$
Age (years)
21.5 ± 9.7
18.0 ± 5.8
0.242
17.2 ± 3.3
17.4 ± 4.1
0.861
BMI age- sex-specific percentiles
84.02 ± 22.07
83.73 ± 14.31
0.970
56.65 ± 25.63
56.79 ± 30.87
0.987
Glucose (mmol/L)
10.0 ± 3.8
10.8 ± 4.1
0.715
5.1 ± 0.4
5.2 ± 0.4
0.133
Fasting plasma insulin levels (pmol/L)
237.21 ± 230.48
112.18 ± 126.24
0.076
52.2 ± 31.1
56.5 ± 32.8
0.602
Ins-30′
—
—
414.67 ± 53.23
582.09 ± 94.71
0.222
Ins-60′
—
—
381.81 ± 51.51
671.57 ± 132.39
0.046
Ins-90′
—
—
379.09 ± 55.41
545.79 ± 107.51
0.280
Ins-120′
—
—
268.32 ± 48.95
375.18 ± 67.10
0.283
AUC-glucose
—
—
832.92 ± 21.83
855.72 ± 17.02
0.422
AUC-insulin
40074.46 ± 4153.74
60457.87 ± 10721.20
0.180
HOMA-B
127.0 ± 194.8
89.89 ± 168
0.685
97.69 ± 70.03
92.98 ± 51.55
0.751
value with Student’s -test.
$ value with Fisher’s exact test.
