Research Article

Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis

Table 3

Shows function of all Essential proteins.

S. no.Accession. no.Celllular componentBiological processMolecular function

1Rv1820Not knownBranched chain family amino acid biosynthetic processAcetolactate synthase activity, magnesium ion binding, thiamine pyrophosphate binding
2.Rv0951Cell wall, cytosolGrowth, tricarboxylic acid cycleATP binding, metal ion binding, succinate-CoA ligase (ADP-forming) activity
3.Rv2987cPlasma membrane, 3-isopropylmalate dehydratase complexGrowth, leucine biosynthetic process3-Isopropylmalate dehydratase activity
4.Rv1475cCell wall, cytosol, extracellular region, plasma membraneGrowth, response to iron ion4 iron, 4 sulfur cluster binding, aconitate hydratase activity, iron-responsive element binding
5.Rv0066cCytosol, extracellular region, plasma membraneTricarboxylic acid cycleNAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, protein homodimerization activity
6.Rv2454cCell wall, cytosolOxidation-reduction process2-Oxoglutarate synthase activity, magnesium ion binding, thiamine pyrophosphate binding
7.Rv1240Cytosol, plasma membraneGlycolysis, malate metabolic process, tricarboxylic acid cycleL-malate dehydrogenase activity, binding
8.Rv1098cCytosol, extracellular region, plasma membraneGrowth, tricarboxylic acid cycleFumarate hydratase activity
9.Rv0247cPlasma membraneTricarboxylic acid cycleElectron carrier activity, iron-sulfur cluster binding, succinate dehydrogenase activity
10.Rv3356cExtracellular region, plasma membraneFolic acid-containing compound biosynthetic process, growth, histidine biosynthetic process, methionine biosynthetic process, one-carbon metabolic process, oxidation-reduction process, purine nucleotide biosynthetic processBinding, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity
11.Rv0951Cell wall, cytosolGrowth, tricarboxylic acid cycleATP binding. metal ion binding, succinate-CoA ligase (ADP-forming) activity
12.Rv0904cAcetyl-CoA carboxylase complex, plasma membraneMycolic acid biosynthetic processATP binding, acetyl-CoA carboxylase activity, protein binding
13.Rv0973cPlasma membraneGrowthATP binding, biotin binding, biotin carboxylase activity
14.Rv1492Cell wall, cytosol, plasma membraneLactate fermentation to propionate and acetate, propionate metabolic process, methylmalonyl pathwayCobalamin binding, metal ion binding, methylmalonyl-CoA mutase activity
15.Rv3667Cell wall, plasma membraneNot knownAMP binding, ATP binding, acetate-CoA ligase activity
16.Rv0409CytoplasmOrganic acid metabolic processATP binding, acetate kinase activity
17.Rv0408Cytoplasm, extracellular regionNot knownPhosphate acetyltransferase activity
18.Rv0243Cytosol, plasma membraneGrowth of symbiont in host cellAcetyl-CoA C-acyltransferase activity
19.Rv0860Cytosol, plasma membraneFatty acid metabolic process, oxidation-reduction processCoenzyme binding, oxidoreductase activity
20.Rv3667Cell wall, plasma membraneNot knownAMP binding, ATP binding, acetate-CoA ligase activity
21.Rv1023Cell surface, extracellular region, phosphopyruvate hydratase complex, plasma membraneGlycolysis, growthMagnesium ion binding, phosphopyruvate hydratase activity
22.Rv1240Cytosol, plasma membraneGlycolysis, malate metabolic process, tricarboxylic acid cycleL-malate dehydrogenase activity, binding
23.Rv0070cNot knownNot knownNot known
24.Rv2205cNot knownOrganic acid phosphorylationGlycerate kinase activity
25.Rv0761cOxidation-reduction processCytoplasm, plasma membranealcohol dehydrogenase (NAD) activity, zinc ion binding
26.Rv0489Plasma membraneGlycolysisPhosphoglycerate mutase activity
27.Rv0363cExtracellular region, plasma membraneGlycolysis, protein homotetramerizationFructose-bisphosphate aldolase activity, zinc ion binding
28.Rv2029cNot knownCarbohydrate metabolic processKinase activity, phosphotransferase activity, alcohol group as acceptor
29.Rv1908cNot knownHydrogen peroxide catabolic process, oxidation-reduction process, response to antibioticCatalase activity, heme binding
30.Rv0070cNot KnownNot KnownNot known
31.Rv0728cNot KnownOxidation-reduction processNAD binding, phosphoglycerate dehydrogenase activity
32.Rv0505cIntegral to plasma membraneNot KnownMetal ion binding, phosphatase activity
33.Rv0884cCytoplasm, extracellular region, plasma membraneL-serine biosynthetic process, growth, pyridoxine biosynthetic processO-phospho-L-serine: 2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding
34.Rv0409CytoplasmOrganic acid metabolic processATP binding, acetate kinase activity
35.Rv0408Cytoplasm, extracellular regionNot knownPhosphate acetyltransferase activity
36.Rv3667Cell wall, plasma membraneNot knownAMP binding, ATP binding, acetate-CoA ligase activity
37.Rv2611cIntegral to membrane, plasma membraneGlycolipid biosynthetic process, growth, lipopolysaccharide core region biosynthetic processAcyltransferase activity
38.Rv0114CytoplasmCarbohydrate metabolic process, histidine biosynthetic processHistidinol-phosphatase activity
39.Rv0113CytoplasmCarbohydrate metabolic processD-sedoheptulose 7-phosphate isomerase activity, metal ion binding, sugar binding
40.Rv1315CytoplasmUDP-N-acetylgalactosamine biosynthetic process, cell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
41.Rv0482CytoplasmCell cycle, cell division, cellular cell wall organization, oxidation-reduction process, peptidoglycan biosynthetic process, regulation of cell shapeUDP-N-acetylmuramate dehydrogenase activity, flavin adenine dinucleotide binding
42.Rv2152cCytoplasmCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, UDP-N-acetylmuramate-L-alanine ligase activity
43.Rv2155cCytosolCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, UDP-N-acetylmuramoylalanine-D-glutamate ligase activity, protein binding
44.Rv2157cCytoplasmCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
45.Rv2156cIntegral to membrane, plasma membraneCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapePhospho-N-acetylmuramoyl-pentapeptide-transferase activity
46.Rv2153cPlasma membraneCell cycle, cell division, cellular cell wall organization, growth, regulation of cell shape, UDP-N-acetylgalactosamine biosynthetic process, lipid glycosylation, peptidoglycan biosynthetic processCarbohydrate binding, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
47.Rv2981cCell wall, cytoplasm, plasma membraneCellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, D-alanine-D-alanine ligase activity, metal ion binding
48.Rv2136cIntegral to membrane, plasma membraneCellular cell wall organization, peptidoglycan biosynthetic process, regulation of cell shape, dephosphorylation, response to antibiotic, response to nitrosative stressUndecaprenyl-diphosphatase activity
49.Rv2158cCytosol, plasma membraneCell cycle, cell division, cellular cell wall organization, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
50.Rv2157cCytoplasmCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapeATP binding, UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
51.Rv2156cIntegral to membrane, plasma membraneCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shapePhospho-N-acetylmuramoyl-pentapeptide-transferase activity
52.Rv2153cPlasma membraneCell cycle, cell division, cellular cell wall organization, growth, peptidoglycan biosynthetic process, regulation of cell shape, UDP-N-acetylgalactosamine biosynthetic processCarbohydrate binding, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
53.Rv3910Integral to plasma membraneNot knownNot known
54.Rv0016cCell septum, cytosol, integral to membrane, plasma membraneCellular cell wall organization, peptidoglycan biosynthetic process, regulation of cell shapePenicillin binding, transferase activity
55.Rv2163cExtracellular regionGrowth, peptidoglycan-based cell wall biogenesisPenicillin binding, protein binding