Conservation and Variability of Synaptonemal Complex Proteins in Phylogenesis of Eukaryotes

Table 2

Eukaryotic SC proteins, their functional domains, and the total protein size (amino acid residues, aa).

SC central space proteins			LE proteins and other SC proteins
Protein	Functional domains^a	Total size, aa	Protein	Functional domains^a	Total size, aa
Zip1 Sc^b	Bacterial SMC, Smc, AAA_13	875	Hop1 Sc	HORMA	605
ZYP1a At	Two bacterial SMC domains	871	Red1 Sc	Rec10/Red1	827
ZYP1b At	Two bacterial SMC domains, PRK00409	856	Hop1 Sp, a linear element component	RING finger	528
C(3)G Dm	Two bacterial SMC domains	744	Rec10 Sp, a linear element component	Rec10/Red1	791
CORONA Dm	—	207	ASY1 At	HORMA, SWIRM	596
SYP-1 Ce	Smc	489	ASY2 At	HORMA	1399
SYP-2 Ce	—	213	C(2)M Dm	Rad21_Rec8_N cohesin domain	570
SYP-3 Ce	SGNH_plant_lipase_like	224	HIM-3 Ce	HORMA	291
SYP-4 Ce	—	605	SYCP2 Dr	—	995
SYCP1 Dr	SCP-1	537	SYCP3-like Dr	COR1	240
SYCE1-like Dr	—	206	SC65 Dr, a SC protein	Bacterial rpoC2_cyan	426
SYCE2 Dr	—	187	SYCP2 Mm	Bacterial COG4399	1500
TEX12 Af	—	135	SYCP3 Mm	COR1	254
SYCP1 Mm	SCP-1	993	SC65 Mm, a SC protein	—	443
SYCE1 Mm	Bacterial SMC	329	FKBP6 Mm, peptidyl-prolyl cis-trans isomerase	FKBP_C, TPR	327
SYCE2 Mm	—	177
SYCE3 Mm	—	88
TEX12 Mm	—	123

aAccording to the CDART output.
^bThe model organisms are designated as in Table 1. See protein IDs in Table 1.
The SMC, Smc, SCP-1, COR1, and RAD21 domains are characteristic of structural chromosome proteins. The HORMA domain recognizes the chromatin state and facilitates the interactions with other proteins. PRK00409 is involved in recombination. Cis-trans isomerases catalyze the isomerization of protein molecules having double bonds. The other domains are not related to meiosis.