Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study
Table 4
Differences in AHI between male and female carriers of the Arg389Gly genotypes of the Beta-1 adrenergic gene.
Gly389Gly/Arg389Gly
Arg389Arg
AHI (events per hour)
Mean
(SE)
Mean
(SE)
(adjusted)
Males
Normotensive subjects
(crude)
20.5
(3.0)
25.9
(2.9)
.20
(adjusted for age)
20.1
(3.1)
26.3
(2.9)
.15
(adjusted for age, BMI)
20.5
(3.0)
25.9
(2.8)
.20
Hypertensive patients
(crude)
26.5
(4.6)
39.5
(3.8)
.03
(adjusted for age)
26.3
(4.6)
39.6
(3.8)
.03
(adjusted for age, BMI)
27.4
(4.5)
38.6
(3.7)
.06
Females
Normotensive subjects
(crude)
23.5
(4.1)
21.3
(3.9)
.70
(adjusted for age)
23.4
(3.9)
21.3
(3.8)
.70
(adjusted for age, BMI)
22.8
(3.7)
21.9
(3.5)
.85
Hypertensive patients
(crude)
24.4
(3.7)
26.0
(3.3)
.76
(adjusted for age)
23.9
(3.6)
26.3
(3.1)
.61
(adjusted for age, BMI)
24.3
(3.6)
26.1
(3.1)
.71
AHI: apnoea-hypopnoea index (events per hour). Data are mean (SE) and stepwise adjusted for age and age and BMI. One male hypertensive had missing BMI.
