Review Article

Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans

Table 4

Genes that have been studied for their effect on hypertension susceptibility or response (pharmacogenes).

PharmacogenesSusceptibility genes

ABCB1CYP3A4ADD1GNAS-EDN3MTHFR
ACECYP3A5AGTGNB3NOS3
ADBR2NAT2APOA5GOSR2NPPA
ADRB1NR3C2ATP2B1NEDD4L
AGTR1SCNN1B2GPR83PLCE1
CACNA1CSLC12A1BAG6GRK4PLEKHA7
CACNA1DSLC12A3CDKAL1HFEPR3
CACNB2SLCO1B1CEP83HSD3B1SH2B3
CES1UGTCHIC2IGF2BP2SLC39A8
CYP1A1CLCNKB1IGFBP3SLC4A7
CYP1A2CNNM2JAG1STK39
CYP2C8CPS1KCNJ1SUB1
CYP2C9CYP11B2LEPTBX5
CYP2D6CYP411LUC7L2TH
CYP2E1EBF1MECOMWNK1
FGF5MOV10WNK4

Genes listed under pharmacogenes are involved in the metabolism of antihypertensive drugs. Genes listed under susceptibility genes have been associated with hypertension in African populations [29]. Highlighted in bold are genes with pharmacogenetic studies done in individuals of African descent.