Resistant or difficult to treat hypertension is an increasingly recognized problem in the United States and around the world. Despite the use of modern pharmacologic therapies and the combination of multiple drug regimens, many patients remained uncontrolled or resistant. The recent advances have allowed us to recognize many secondary causes of resistance and allowed better treatment of such patients. In many patients with resistant hypertension and no identifiable causes, neurogenic or cardiorenal mechanisms have been implicated. In the recent years, technologies have been developing to address many of these patients. Researches with baroreceptor stimulation therapies and sympathetic renal denervation are well under way with exiting results.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the pathophysiology of resistant hypertension, the development of strategies to treat these patients, and the evaluation of outcomes.

We are particularly interested in articles describing the pathophysiology of neurogenic hypertension, the role of baroreceptors and renal innervations, and therapeutic approaches, involving innovative pharmacologic approaches and device therapies.

Potential topics include, but not limited to:

• Recent developments in the pathophysiology of resistant hypertension
• Frequent secondary causes of resistant hypertension
• Work-up and approach to pharmacologic therapy
• Baroreceptor activity and blood pressure control
• Baroreceptor stimulation for resistant hypertension—focusing on the Rheos device
• Renal sympathetic innervations and blood pressure control
• Renal sympathetic denervation for resistant hypertension—focusing on radiofrequency ablation
• Other potential energy sources for renal denervation, as compared to surgical sympathectomy and robotic renal denervation
• Potential benefits from blood pressure control in patients with resistant hypertension

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijht/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: