| | Mice strains | I/R models | I/R protocols | MI | Cardiac function | Inflammation | | TLRs | NF-κB activity | Cytokine production |
Myocardial neutrophil infiltration | EC dysfunction/ROS ↑ | Ref. | | Myocardium |
Serum | | | mRNA | Protein | |
| TLR2 | TLR2−/−, TIRAP−/− | ex vivo | 30′ I/60′ R | | ↑ | | |
TNFα, IL-1β | | | | [86] | TLR2−/− | in vivo | 30′ I/1 h R | ↓ | | | IL-1β | | | ↓ | ↓ | [87] | TLR2−/− chimeric, WT with Anti-TLR2 | in vivo | 30′ I/24 h R | ↓ | ↑ | | |
TNFα, IL-1β, IL-10, M-CSF | | ↓ | | [88] | TLR2−/−, WT with Anti-TLR2 | in vivo | 20′ I/24 h R | ↓ | | | | | | ↓ | | [89] |
| TLR4 | C57BL/10 ScCr C3H/HeJ | in vivo | 60′ I/24 h R | ↓ | | | | | | ↓ | | [90] | C3H/HeJ | in vivo | 60′ I/2 h R | ↓ | | ↓ |
TNFα, IL-1β, MCP-1, IL-6 | | | | | [91] | WT with Eritoran | in vivo | 30′ I/2 h R | ↓ | | |
TNFα, IL-1β, MCP-1, IL-6, MIP-1, MIP-2 | | | | | [92] | C3H/HeJ | in vivo | 60′ I/2 h, 24 h R | ↓ | NS | |
TNFα, IL-1β, IL-6 | |
TNFα, IL-1β, IL-6 | | | [93] | C57BL/10 ScCr C3H/HeJ | ex vivo | 20′ I/60′ R | | ↑ | ↓ | |
TNFα, IL-1β | | | | [94] | WT with Anti-HSC70 | ex vivo | 20′ I/60′ R | | ↑ | |
TNFα, IL-1β, IL-6 |
TNFα, IL-1β, IL-6 | | | | [95] | C3H/HeJ | ex vivo | HSC70 | | ↑ | ↓ |
TNFα, IL-1β, IL-6 |
TNFα, IL-1β, IL-6 | | | | [95] | C3H/HeJ | ex vivo | 20′ I/60′ R | | | |
KC, MCP-1 |
KC, MCP-1 | |
perfused NE↓ | | [96] | C3H/HeJ | in vivo | transplantation 2 h I/3 h, 24 h R | | | ↓ |
TNFα, IL-1β, IL-6, ICAM-1 | |
TNFα, IL-1β, IL-6, ICAM-1 | ↓ | | [97] |
| MyD88 | WT with Ad-dnMyD88 | in vivo | 45′ I/4 h R | ↓ | | ↓ | | | | | | [98] | MyD88−/− | in vivo | 30′ I/24 h R | ↓ | ↑ | |
MCP-1, KC, ICAM-1 | | | ↓ | | [99] | MyD88−/− | ex vivo | 20′ I/40′ R | NS | NS | | | | | | | [99] | MyD88−/− chimeric | in vivo | 30′ I/24 h R | ↓ | | | |
NS | | ↓ | | [100] |
| Others | CD14−/−, MyD88−/−, Trif−/− | in vivo | transplantation 2 h I/3 h, 24 h R | | | ↓ |
TNFα, IL-1β, IL-6, ICAM-1 | |
TNFα, IL-1β, IL-6, ICAM-1 | ↓ | | [101] |
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