Angiotensin-Converting Enzyme-2 (ACE-2) with Interferon-Induced Transmembrane Protein-3 (IFITM-3) Genetic Variants and Interleukin-6 as Severity and Risk Predictors among COVID-19 Egyptian Population
Table 7
Univariate and multivariate logistic regression analyses for predictors of COVID-19 progression among the studied cases: severe and critical vs. mild/moderate cases (n = 120 vs. 40).
Parameters
Univariate
#Multivariate
OR (LL–UL 95% CI)
OR (LL–UL 95% CI)
ACE2 (rs2285666) (CT + TT)
<0.001
15.0 (6.336–35.511)
<0.001
12.136 (2.784–52.896)
IFITM-3 (rs12252) (AG + GG)
<0.001
9.841 (4.357–22.23)
<0.001
17.276 (3.673–81.249)
IL-6 level (1st reading)
<0.001
1.024 (1.011–1.037)
0.002
1.032 (1.012–1.052)
CRP
0.005
1.017 (1.005–1.030)
0.669
1.006 (0.980–1.032)
D-dimer
<0.001
1.003 (1.001–1.005)
0.089
1.003 (1.000–1.005)
Ferritin
<0.001
1.005 (1.003–1.007)
0.676
1.000 (0.998–1.002)
Lymphopenia
0.426
1.362 (0.636–2.917)
Comorbidities
0.001
3.778 (1.686–8.467)
0.099
8.019 (0.674–95.44)
Age (years)
0.012
1.030 (1.007–1.054)
0.711
1.010 (0.956–1.068)
Female
1.000
1.000 (0.482–2.076)
OR: odds ratio. CI: confidence interval. LL: lower limit. UL: upper limit. #All variables with were included in the multivariate analysis. Statistically significant at .
