Comparison of Three Glomerular Filtration Rate Estimating Equations with 24-Hour Urine Creatinine Clearance Measurement in Potential Living Kidney Donors
Table 3
Accuracy, precision, and agreement comparing the MDRD, CKD-EPI, and CG equations for the entire cohort and separated by subgroups.
Estimation method
Accuracy and precision
Agreement
Bias (SD bias)
Upper limit of agreement (ULoA) (95% CI)
Lower limit of agreement (LLoA) (95% CI)
MDRD
13.8 (25.3)
63.5 (60.5 to 66.5)
−35.8 (−38.8 to −32.8)
Male
19.5 (27.0)
72.4 (67.6 to 77.2)
−33.3 (−38.1 to −28.5)
Female
9.2 (22.9)
54.2 (50.6 to 57.9)
−35.7 (−39.4 to −32.0)
BMI >25
20.3 (26.2)
71.6 (67.1 to 76.1)
−31.0 (−35.5 to −26.5)
BMI <25
7.9 (23.0)
53.1 (49.3 to 56.9)
−37.1 (−40.9 to −33.4)
Age <40
11.9 (26.2)
63.3 (59.1 to 67.4)
−39.4 (−43.5 to −35.2)
Age >40
16.3 (23.9)
63.3 (58.9 to 67.6)
−30.6 (−34.9 to −26.2)
CKD-EPI
9.8 (24.8)
58.6 (55.7 to 61.6)
−38.8 (−41.8 to −35.9)
Male
17.7 (25.4)
67.7 (63.1 to 72.2)
−32.2 (−36.7 to −27.6)
Female
3.5 (22.5)
47.6 (44.1- to 51.2)
−40.5 (−44.1 to −36.9)
BMI >25
16.6 (25.3)
66.3 (61.9 to 70.7)
−33.1 (−37.4 to −28.7)
BMI <25
3.7 (22.7)
48.4 (44.7 to 52.2)
−40.8 (−44.6 to −37.1)
Age <40
6.7 (25.4)
56.6 (52.6 to 60.6)
−43.0 (−47.0 to −39.0)
Age >40
13.9 (23.5)
60.1 (55.9 to 64.4)
−32.2 (−36.5 to −27.9)
CG
5.8 (25.1)
55.1 (52.1 to 58.0)
−43.4 (−46.3 to −40.4)
Male
8.7 (24.9)
57.7 (53.2 to 62.2)
−40.2 (−44.6 to −35.7)
Female
3.5 (25.0)
52.5 (48.5 to 56.5)
−45.5 (−49.5 to −41.5)
BMI >25
0.2 (27.3)
53.8 (49.0 to 58.5)
−53.2 (−58.0 to −48.5)
BMI <25
10.9 (21.7)
53.6 (50.0 to 57.2)
−31.7 (−35.3 to −28.2)
Age <40
1.6 (25.9)
52.5 (48.4 to 56.6)
−49.3 (−53.4 to −45.2)
Age >40
11.4 (22.8)
56.1 (52.0 to 60.2)
−33.2 (−37.4 to −29.1)
Note: SD: standard deviation; ULoA: upper limit of agreement; LLoA: lower limit of agreement; CI: confidence interval; MDRD: modification of diet in renal disease; CKD-EPI: chronic kidney disease epidemiology collaboration; CG: Cockcroft–Gault.
