Somatic Symptoms of Depression Lose Association with Mortality upon Adjustment for Frailty: Analysis from the Fitness Haemodialysis Cohort

Table 1

Baseline demographics stratified by frailty status.

		Total cohort	Not frail	Frail
Frail		261	—	—
		53.8%	—	—
Median age		63	60	65
		53–74	50–72	55–76
Median CFS score		5	3	5
		3–6	3–4	5-6
Median PHQ-9 score		5	3	7
		2–10	1–7	3–12
Moderate depression		127	33	94
		26.5%	14.8%	36.6%
Median PHQ-9 somatic score		3	2	4
		1–6	1–4	2–6
Median PHQ-9 cognitive score		1	1	3
		0–5	0–3	0–6
Median MoCA		22	23	20
		17–25	20–26	16–23
Median albumin (g/L)		39	39	38
		35–41	36–42	34–41
Median BMI		26.8	26	27.9
		23.2–32.3	23.0–30.7	23.2–33.7
Median Charlson score		4	4	5
		3–6	2–5	4–7
Median HD vintage (months)		37	33	41
		17–76	13–66	19.9–81.5
Median Kt/V		1.59	1.58	1.61
		1.39–1.85	1.38–1.80	1.41–1.88
Median EQ summary index		0.779	1	0.62
		0.516–1.00	0.779–1.00	0.189–0.796
Health change	Better	94	52	42
		19.4%	23.2%	16.1%
	The Same	174	90	84
		35.9%	40.2%	32.2%
	Worse	217	82	135
		44.7%	36.6%	51.7%
IMD quintile	1	212	96	116
		43.7%	42.9%	44.4%
	2	87	43	44
		17.9%	19.2%	16.9%
	3	85	38	47
		17.5%	17.0%	18.0%
	4	38	20	18
		7.8%	8.9%	6.9%
	5	33	14	19
		6.8%	6.3%	7.3%
	Unknown	30	13	17
		6.2%	5.8%	6.5%
Ethnicity	White	281	13	144
		57.9%	61.2%	55.2%
	South Asian	115	44	71
		23.7%	19.6%	27.2%
	Black	76	35	41
		15.7%	15.6%	15.7%
	Other	13	8	5
		2.7%	3.6%	1.9%
Gender	Male	284	148	136
		58.6%	66.1%	52.1%
Comorbidities	Diabetes	138	43	95
		28.5%	19.2%	36.4%
	MI	98	34	64
		20.2%	15.2%	24.5%
	CVA/TIA	57	17	40
		11.8%	7.6%	15.3%
	Cancer	56	30	26
		11.6%	13.4%	10.0%
	Heart failure	52	19	33
		10.7%	8.5%	12.6%
	PVD	47	15	32
		9.7%	6.7%	12.3%
Primary renal disease	Diabetic	114	33	81
		23.5%	14.7%	31.3%
	Hypertensive	39	22	17
		8.0%	9.8%	6.5%
	Ischaemic	38	14	24
		7.8%	6.3%	9.2%
	IgA	37	20	17
		7.6%	8.9%	6.5%
	PKD	28	17	11
		5.8%	7.6%	4.2%
	FSGS	24	14	10
		5.0%	6.3%	3.8%
	Reflux	17	7	10
		3.5%	3.1%	3.8%
	Obstructive	16	10	6
		3.3%	4.5%	2.3%
	AAV	15	11	4
		3.1%	4.9%	1.5%
	Interstitial nephritis	10	6	4
		2.1%	2.7%	1.5%
	Myeloma	10	8	2
		2.1%	3.6%	0.8%
	Unknown	68	31	37
		14.0%	13.8%	14.2%
Smoking status	Current	68	38	30
		14.1%	17.0%	11.5%
	Ex	132	64	68
		27.3%	28.6%	26.2%
	Never	284	122	162
		58.7%	54.5%	62.3%
Dialysis access	Line	113	47	66
		23.3%	21.0%	25.3%
Transplant list status	Active	58	36	22
		12.0%	16.1%	8.4%
	Suspended	15	9	6
		3.1%	4.0%	2.3%
	Not listed	412	179	233
		85.0%	79.9%	89.3%
Employment status	Employed	69	61	8
		14.3%	27.2%	3.1%
	Unemployed	148	58	90
		30.6%	25.9%	34.6%
	Retired	267	105	162
		55.2%	46.9%	62.3%
Job role†	Unskilled manual	181	70	111
		39.3%	32.1%	45.7%
	Skilled manual	101	50	51
		21.9%	22.9%	21.0%
	Clerical	52	28	24
		11.3%	12.8%	9.9%
	Managerial	46	26	20
		10.0%	11.9%	8.2%
	Professional	81	44	37
		17.6%	20.2%	15.2%
Education level	High School	342	146	196
		70.7%	65.2%	75.4%
	College/Sixth Form	92	49	43
		19.0%	21.9%	16.5%
	University	50	29	21
		10.3%	13.0%	8.1%
Residence	Own home	462	218	244
		95.9%	97.8%	94.2%
	Warden-controlled	12	3	9
		2.5%	1.4%	3.5%
	Residential home	5	2	3
		1.0%	0.9%	1.2%
	Nursing home	3	0	3
		0.6%	0.0%	1.2%

All values n and percentages except where the median stated (median and interquartile range); Frail = CFS ≥5; PHQ-9 score ≥10; CKD omitted; and †or previous occupation if unemployed/retired.