Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light
Figure 3
(a) Schematic representation of the LightOn system. After light activation, GAVP homodimerizes, interacts with UASG elements (5xUASG), and initiates expression of the gene of interest. Adapted with permission from Macmillan Publishers Ltd. (Nature Publishing Group): Nature Methods [51], copyright (2012). (b) Schematic of the LITE system. Light stimulation induces dimerization of CRY2 and CIB1, recruiting the effector to the target promoter. Adapted with permission from Macmillan Publishers Ltd. (Nature Publishing Group): Nature [63], copyright (2013).
