Antiepileptic Effects of Lacosamide Loaded Polymers Implanted Subdurally in GAERS

Table 1

Postoperative health monitoring chart. For a minimum of three days after surgery and until full recovery from the surgery, the rats were monitored for weight loss once a day and for mobility and grooming twice a day. For each day a debilitation score was calculated by cumulating the highest grooming and mobility scores with the weight loss score. A debilitation score of 0, 1 to 3, 4 to 6, and 7 to 9 meant that the rat health was not affected, middle affected, moderately affected, and severely affected by the surgery/polymer implantation, respectively.

Postoperative health monitoring chart	Score
Percentage of weight loss
No weight loss	0
Less than 10% weight loss	1
10% to less than 20% weight loss	2
20% or more weight loss	3
Mobility score
Rat moving normally	0
Rat ataxic moving at a normal speed	1
Rat ataxic and moving slowly	2
Rat recumbent	3
Grooming score
No decrease in grooming activity	0
Middle decrease in grooming activity	1
Moderate decrease in grooming activity	2
No grooming activity	3
Total score = debilitation score	0–9