Association of Cytokine IL-17, IL-4, IL-6, and IL-12 Gene Polymorphisms in Rheumatoid Arthritis Patients in a Tertiary Care Hospital in Bangladesh
Table 3
Comparison of genotype distribution and allele frequencies of IL-17F (7488 A/G), IL-12B (1188 A/C), IL-4 (590C/T), and IL-6 (174 G/C) polymorphisms in patients with rheumatoid arthritis and healthy subjects ().
Genotype and allele
Patients ()
Healthy subjects ()
OR (95% CI)
value
IL-17F (7488A/G)
AA
3 (7.5%)
18 (45%)
0.09 (0.02-0.34)
0.019
AG
25 (62.5%)
20 (50%)
1.66 (0.68-4.04)
0.650
GG
12 (30%)
2 (5%)
8.56 (1.77-41.33)
0.006
G allele
49 (61.2%)
24 (30%)
3.67 (1.90-7.07)
0.039
A allele
31 (38.8%)
56 (70%)
IL-12B(1188A/C)
AA
7 (17.5%)
28 (70%)
0.09 (0.03-0.26)
0.001
AC
22 (55%)
10 (25%)
3.69 (1.43-9.53)
0.012
CC
11 (27.5%)
2 (5%)
7.58 (1.56-36.88)
0.013
C allele
38 (47.5%)
24 (30%)
2.11 (1.10-4.04)
0.023
A allele
42 (52.5%)
56 (70%)
IL-4 (590C/T)
CC
—
—
—
—
CT
25 (62.5%)
15 (37.5%)
2.78 (1.12-6.87)
0.05
TT
15 (37.5%)
25 (62.5%)
0.36 (0.15-0.89)
0.05
T allele
55 (68.7%)
65 (81.3%)
0.50 (0.24-1.04)
0.195
C allele
25 (31.3%)
15 (18.7%)
IL-6 (174 G/C)
GG
40
40
GC
—
—
CC
—
—
value was determined by chi-square test; value < 0.05 indicates significance.
