Review Article
Prognostic Value of KRAS Gene Mutation on Survival of Patients with Peritoneal Metastases of Colorectal Adenocarcinoma
Table 2
KRAS mutation status according to patient and tumour characteristics.
| | WT-KRAS (n = 74) | MT-KRAS (n = 75) | value |
| Sex | Men (n = 85) | 43 (50.6%) | 42 (49.4%) | 0.46 | Women (n = 64) | 31 (48.4%) | 33 (51.6%) |
| Age | <50 (n = 17) | 9 (53%) | 8 (47%) | 0.62 | 50–69 (n = 80) | 42 (52.5%) | 38 (47.5%) | >69 (n = 52) | 23 (44.2%) | 29 (55.8%) |
| Location | Right colon (n = 64) | 28 (43.7%) | 36 (56.3%) | 0.32 | Left colon (n = 64) | 33 (51.5%) | 31 (48.5%) | Rectum (n = 21) | 13 (61.9%) | 8 (38.1%) |
| ECOG Index | 0 (n = 34) | 20 (58.8%) | 14 (41.2%) | 0.15 | 1-2 (n = 115) | 54 (46.9%) | 61 (53.1%) |
| T stage | T3 (n = 68) | 33 (48.5%) | 35 (51.5%) | 0.46 | T4 (n = 81) | 41 (50.6%) | 40 (49.4%) |
| N stage | N0 (n = 27) | 18 (66.6%) | 9 (33.4%) | 0.04 | N1-2 (n = 122) | 56 (45.9%) | 66 (54.1%) |
| Time of diagnostics | Synchronic (n = 77) | 36 (46.7%) | 41 (53.3%) | 0.28 | Metachronic (n = 72) | 38 (52.8%) | 34 (47.2%) |
| Site of metastases | Peritoneum only (n = 61) | 36 (59%) | 25 (41%) | 0.08 | Peritoneum + liver (n = 51) | 26 (51%) | 25 (49%) | Peritoneum + lung (n = 8) | 3 (37.5%) | 5 (62.5%) | Multiple (n = 29) | 9 (31%) | 20 (69%) |
| Grade of differentiation | Well to moderate (n = 111) | 61 (55%) | 50 (45%) | 0.02 | Poor (n = 38) | 13 (34.2%) | 25 (65.8%) |
| Histologic type | Classic adenocarcinoma (n = 105) | 61 (58%) | 43 (42%) | <0.001 | Mucinous (n = 44) | 12 ((27.7%) | 32 (73.8%) |
| Peritoneal cancer index | 1–10 (n = 46) | 23 (50%) | 23 (50%) | 0.15 | 11–20 (n = 63) | 36 (57.1%) | 27 (42.9%) | >20 (n = 40) | 15 (37.5%) | 25 (62.5%) |
| Primary tumour resection | Yes (n = 130) | 69 (53%) | 61 (47%) | 0.02 | No (n = 19) | 5 (26.3%) | 14 (73.7%) |
| Chemotherapy treatment | 5-FU-based programs plus bevacizumab/cetuximab (n = 103) | 57 (55%) | 46 (45%) | 0.51 | 5-FU-based programs (n = 46) | 17 (37%) | 29 (63%) |
| HIPEC | No (n = 113) | 50 (44.2%) | 63 (55.8%) | 0.01 | Yes (n = 36) | 24 (66.6%) | 12 (33.4%) |
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A χ2 test was used to calculate the values. |