High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

Table 5

Kaplan–Meier (log-rank statistic) analysis for overall survival and disease-free survival (n = 100).

Variable	Total	OS in months		95% CI		DFS in months		95% CI
		Median		Lower	Upper	Median		Lower	Upper
Gender
Male	57	100	0.597	37.7	162.3	51	0.629	28.1	73.9
Female	43	85		30.1	139.4	58		35.4	80.6
Age division
<40 years	18	155	0.93			31	0.376	0	80.9
>40 years	82	100		60.2	139.8	52		35.1	69
Primary tumour site
Cheek	63	85	0.287	46.6	123.4	44	0.045	21.6	66.4
Tongue	37	155				58		20.1	95.8
Tonsil
Yes	2	9	<0.001			5	0.001
No	98	100		53.1	146.9	53		40.8	65.2
Skin
Yes	3	25	0.082	4.2	45.8	7	0.031	2.2	11.9
No	97	104		54.6	153.5	53		37.1	68.9
Neck pathology
Positive	27	31	0.001	0	102.2	69	0.018	51.8	86.2
Negative	51	155				22		0	52.5
ND	22	64		13	115	27		4	50
Pathologically involved lymph nodes
Single	16	59	0.001	2.2	115.8	29	0.078	0	85.8
Multiple	11	12		6.6	17.4	6		2.8	9.2
NA	73	149		85.4	212.6	58		40.9	75.1
Primary margins
Clear	62	149	0.004	88.5	209.5	62	0.008	49	75
Near	27	62		23.2	100.8	24		0	76.6
Involved	11	13		9.8	16.2	7		0	15.6
N classification
N0	77	149	<0.001	79.2	218.8	58	0.024	48.6	67.4
N1	13	31		11.6	50.4	27		5.9	48.1
N2	10	12		9	15	6		2.9	9.1
AJCC stage
I	19	249	0.002	34.7	463.3	69	0.03	51.8	86.3
II	32	149		82.5	215.5	58		39.7	76.3
III	23	68		47.5	88.5	51		22.8	79.2
IV	26	14		0	30.2	9		2	16
Radiotherapy
Yes	65	68	0.026	43.5	92.5	44	0.242	18.3	69.7
No	35					62		35	89
CD44
High	33	64	0.047	46.8	81.2	45	0.24	11.2	78.8
Low	67	106		39.9	172.1	57		39.3	74.7
CD133
Positive	23		0.613			57	0.996	35.1	79
Negative	77	100		55.5	144.5	52		24.5	79.6
L1CAM
Positive	41	74	0.489	42.7	105.3	44	0.266	5.1	82.9
Negative	59	122		42.4	201.6	53		40.2	65.8
SOX2
Positive	63	100	0.318	53.7	146.3	53	0.483	39.8	66.2
Negative	37	68			136.4	51		0	104.6

taken as significant.