Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study
Table 3
Logistic regression models comparing aortic stiffness indices of participants in the upper tertile of angiogenic growth factors to those in the lower tertile.
Crude OR (95% CI)
Adjusted OR (95% CI)
Angiopoietin-1
PWV
1.42 (1.07–1.69)
0.007
1.27 (0.96–1.87)
0.066
AIx
1.03 (0.99–1.1)
0.211
1.01 (0.97–1.05)
0.73
Aortic systolic BP
1.19 (1.04–1.35)
0.001
1.02 (0.97–1.07)
0.488
Aortic PP
1.08 (1.01–1.19)
0.033
1.03 (0.98–1.08)
0.255
Angiopoietin-2
PWV
2.83 (1.23–4.01)
<0.001
2.01 (1.17–3.84)
0.004
AIx
1.53 (1.13–1.84)
0.001
0.84 (0.71–0.96)
0.014
Aortic systolic BP
1.24 (1.09–1.4)
0.002
1.24 (1.04–1.97)
0.011
Aortic PP
1.31 (1.09–1.53)
0.006
1.19 (1.04–1.82)
0.041
VEGF
PWV
1.06 (0.82–1.37)
0.636
0.93 (0.67–1.28)
0.929
AIx
1.02 (0.99–1.05)
0.141
1.03 (0.98–1.08)
0.405
Aortic systolic BP
1.01 (0.99–1.03)
0.238
1.03 (0.99–1.08)
0.81
Aortic PP
1.01 (0.99–1.03)
0.339
1.01 (0.96–1.09)
0.812
BP: blood pressure; PP: pulse pressure; PWV: aortic pulse wave velocity; AIx: aortic augmentation index; VEGF: vascular endothelial growth factor. adjusted for age, gender, diabetes, and hypertension status, BMI, and mean BP.
