Review Article
Liver Transplantation for Hepatocellular Carcinoma beyond Milan Criteria: Multidisciplinary Approach to Improve Outcome
Table 2
Results of TACE as neoadjuvant therapy prior to LT in patients with HCC initially beyond MC.
| | Author (year) | Inclusion criteria | Transplant criteria | Outcome after LT |
| | Graziadei et al. (2003) [206] | Beyond Milan
() | ≥50 tumor regression under TACE | 31% (intent-to-treat) 5-year overall survival |
| | Millonig et al. (2007) [207] | Within UCSF
Beyond UCSF | No progression beyond UCSF
≥50 tumor destruction | 66.6% (response)/25% (progression)
25% 5-year overall survival |
| | Otto et al. (2006) [208] | Beyond Milan () | Tumor regression under TACE | 74.5% 5-year overall survival |
| | Ravaioli et al. (2008) [209] | Single HCC nodule ≤8 cm
or bifocal HCC ≤5 cm
or <6, each ≤4 cm, TTD ≤ 12 cm
No macrovascular invasion | Downstaging into Milan criteria
(TACE or resection or RFA) | 75% 3-year recurrence-free survival |
| |
de Luna et al. (2009) [210] | Beyond Milan criteria | Downstaging into Milan criteria | 78.8% 3-year overall survival |
| |
Jang et al. (2010) [211] | Beyond Milan criteria | Downstaging into Milan criteria | 66.3% 5-year recurrence-free survival |
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