Review Article

Liver Transplantation for Hepatocellular Carcinoma beyond Milan Criteria: Multidisciplinary Approach to Improve Outcome

Table 4

Novel approaches of extending selection criteria.

Author (year)Selection criteriaOutcome after LT

Yang et al. (2006) [131] 18F-FDG-PET
(negative versus positive)
12% recurrence rate PET− patients
36.5% recurrence rate PET+ patients

Kornberg et al. (2009) [132] 18F-FDG-PET
(negative versus positive)
11.1% recurrence rate Milan Out/PET−
53.8% recurrence rate Milan Out/PET+

Kornberg et al. (2012) [135] 18F-FDG-PET
(negative versus positive)
5-year recurrence-free survival:
86.2% Milan In
81% Milan Out/PET−
21% Milan Out/PET+

Halazun et al. (2009) [160]NLR
(< versus ≥5)
5-year recurrence-free survival:
75% in NLR <5
25% in NLR ≥5

An et al. (2012) [163]CRP
(< versus ≥1 mg/dL)
CRP independent predictor of outcome
HR 4.64 recurrence-free survival
HR 2.68 overall survival

Schwartz et al. (2008) [174]Allelic imbalance
(≤ versus >0.27)
Tumor recurrence probability at 5 years:
10% in AI ≤0.27
85% in AI >0.27

Jonas et al. (2009) [176]DNA index
(≤ versus >1.5)
5- and 10-year survival rate in Milan Out
72% and 68% in DNA ≤1.5
26% and 3% in DNA >1.5