Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock

Table 2

CuCl catalysed solvent-free synthesis of dihydropyrimidin-2(1H)-ones and thiones under microwaves (Scheme 2).

Compound	R	X	Time (min) isolated yield (%)		MP (°C)
					Found	Reported
4a	C6H5	O	2.5	94	197–199	200–202 [29]
4b	2-Cl C6H5	O	2.0	98	215–217	216–218 [44]
4c	4-Cl C6H5	O	2.4	97	210–212	211–213 [44]
4d	4-HO C6H5	O	2.5	96	200–202	198–200 [29]
4e	2-NO2 C6H5	O	2.5	90	207–209	206–208 [44]
4f	3-NO2 C6H5	O	2.0	89	226–228	229-230 [44]
4g	4-OMe	O	2.5	96	203-204	201-202 [29]
4h	CH3CH2CH2	O	2.5	70	178–180	180–182 [44]
4i	(CH3)2CH	O	2.5	88	195–197	196-197 [44]
4j	C6H5	S	3.0	89	201–203	202–204 [29]
4k	3-NO2 C6H5	S	3.5	85	203–205	206-207 [29]
4l	4-Cl C6H5	S	3.0	92	181–183	184-185 [29]
4m	4-HO C6H5	S	3.5	88	192–194	193-194 [29]