Characterization of the Active Ingredient and Prediction of the Potential Mechanism of Dahuoluo Pill via Mass Spectrometry with the Network Pharmacology Method

Table 4

The information of 15 key targets.

Gene name	Target	UniProt ID	Degree
AKT1	Serine/threonine-protein kinase AKT	P31749	52
STAT3	Signal transducer and activator of transcription 3	P40763	50
MAPK1	c-Jun N-terminal kinase 3	P53779	50
VEGFA	Vascular endothelial growth factor A	P15692	48
MAPK8	c-Jun N-terminal kinase 1	P45983	45
EGFR	Epidermal growth factor receptor ErbB1	P00533	44
TNF	TNF-alpha	P01375	43
SRC	Tyrosine-protein kinase SRC	P12931	38
HRAS	Transforming protein p21/H-Ras-1	P01112	36
CTNNB1	Axin1/beta-catenin	P35222	34
JUN	Proto-oncogene c-JUN	P05412	33
APP	Beta-amyloid A4 protein	P05067	33
PTGS2	Cyclooxygenase-2	P35354	31
RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	30
IL2	Interleukin-2	P60568	29
TLR4	Toll-like receptor 4 (by homology)	O00206	28
IL1B	Interleukin-1 beta	P01584	28
CASP3	Caspase-3	P42574	24