Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion

Table 1

The parameter of microwave digestion.

Sample mass (g)	Reagents added	Initial temperature (°C)	Ramp (min)	Target temperature (°C)	Hold (min)
0.2	5 mL of nitric acid, 50 µL of hydrofluoric acid, 0.2 mL of ICP standard Gold	Room temperature	10	120	2
		120	5	150	5
		150	6	190	55