Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion

Table 7

Results of specificity.

Elements		Blank	Sample blank	LOQ-1	LOQ-2	LOQ-3
Cd	Cd intensity (cps)	9	34	2282	2191	2293
	In intensity (cps)	243566	252744	237720	236767	237321
	Ratio (Cd/In)	0.000037	0.000135	0.009600	0.009254	0.009662
Pb	Pb intensity (cps)	7437	17912	68587	65069	66530
	Bi intensity (cps)	1728776	1729057	1628737	1626974	1633924
	Ratio (Pb/Bi)	0.004302	0.010359	0.042111	0.039994	0.040718
As	As intensity (cps)	7	9	1519	1498	1534
	Y intensity (cps)	162544	167769	158447	155792	157899
	Ratio (As/Y)	0.000043	0.000054	0.009587	0.009615	0.009715
Hg	Hg intensity (cps)	914	814	46330	45671	45876
	Bi intensity (cps)	1728776	1729057	1628737	1626974	1633924
	Ratio (Hg/Bi)	0.000529	0.000471	0.028445	0.028071	0.028077
Co	Co intensity (cps)	239	225	111883	108341	110411
	Y intensity (cps)	162544	167769	158447	155792	157899
	Ratio (Co/Y)	0.001470	0.001341	0.706123	0.695421	0.699251
V	V intensity (cps)	78	44	76045	74348	75912
	Y intensity (cps)	162544	167769	158447	155792	157899
	Ratio (V/Y)	0.000480	0.000262	0.479940	0.477226	0.480763
Ni	Ni intensity (cps)	3364	5208	129662	129676	130188
	Y intensity (cps)	162544	167769	158447	155792	157899
	Ratio (Ni/Y)	0.020696	0.031043	0.818330	0.832366	0.824502