Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion

Table 8

Accuracy of 7 elements in rosuvastatin calcium tablets.

Analyte	Added (µg·L^−1)	Found (µg·L^−1)	Recovery (%)
Cd	0.5 (50%)	0.506, 0.506, 0.518	100.4, 100.4, 102.8
	1 (100%)	1.002, 1.020, 0.977	99.8, 101.6, 97.3
	1.5 (150%)	1.501, 1.486, 1.488	99.8, 98.8, 98.9
	Average	—	99.8
Pb	0.5 (50%)	0.545, 0.544, 0.545	101.4, 101.2, 101.4
	1 (100%)	1.056, 1.074, 1.054	101.8, 103.6, 101.6
	1.5 (150%)	1.582, 1.554, 1.584	102.9, 101.1, 103.1
	Average	—	102.0
As	1.5 (50%)	1.427, 1.425, 1.455	94.6, 94.5, 96.5
	3 (100%)	2.853, 2.907, 2.845	94.8, 96.6, 94.6
	4.5 (150%)	4.280, 4.281, 4.253	94.9, 95.0, 94.3
	Average	—	95.1
Hg	3 (50%)	2.753, 2.764, 2.782	91.8, 92.1, 92.7
	6 (100%)	5.616, 5.581, 5.532	93.6, 93.0, 92.2
	9 (150%)	8.455, 8.383, 8.428	93.9, 93.1, 93.6
	Average	—	92.9
Co	5 (50%)	4.877, 4.907, 4.937	96.3, 96.9, 97.5
	10 (100%)	9.721, 9.707, 9.601	96.6, 96.4, 95.4
	15 (150%)	14.455, 14.432, 14.316	96.0, 95.8, 95.0
	Average	—	96.2
V	10 (50%)	10.234, 10.169, 10.292	97.6, 97.0, 98.2
	20 (100%)	20.045, 19.918, 19.755	97.9, 97.2, 96.4
	30 (150%)	29.398, 29.376, 29.304	96.4, 96.3, 96.1
	Average	—	97.0
Ni	20 (50%)	19.372, 19.422, 19.648	96.0, 96.3, 97.4
	40 (100%)	38.757, 38.859, 38.380	96.5, 96.7, 95.5
	60 (150%)	57.217, 57.290, 56.764	95.1, 95.2, 94.3
	Average	—	95.9

The concentration of Cd was 0.002 µg·L⁻¹, Pb was 0.019 µg·L⁻¹, As was 0.0038 µg·L⁻¹, Co was 0.031 µg·L⁻¹, V was 0.2354 µg·L⁻¹, and Ni was 0.0822 µg·L⁻¹.