SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

Figure 2

Functional domains of the PPAR family are represented schematically. Ligand-dependent activation domain (AF-1) consists of domains A/B, DNA-binding domain (C), and domain D. Ligand-dependent activation function (AF-2) consists of domains E/F and forms the ligand binding site with important molecular recognition interactions in the receptor. hPPARγ1 is the largest isoform (477 AAs). (Modified from [15]).