SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

Figure 3

Rosiglitazone (RGZ) takes U shape in the Y-shaped active site of PPARγ (PDB code: 2PRG). The TZD ring forms hydrogen-bonding interactions with HIS323, HIS449, and TYR473 in the active site. Figure is generated using LigSite [17] and PyMol [18].