Research Article
Computational Simulation of Tumor Surgical Resection Coupled with the Immune System Response to Neoplastic Cells
Table 1
Parameters defining a competent and an incompetent immune system for a given tumor (modified from [
13]).
| | Parameter | Units | Meaning | Competent | Incompetent |
| | Day−1 | Tumor growth rate | 5.14 × 10−1 | 5.14 × 10−1 | | Cell−1 | is tumor carrying capacity | 1.02 × 10−9 | 1.02 × 10−9 | | Cell−1 day−1 | Fractional tumor cell kill by NK cells | 3.23 × 10−7 | 3.23 × 10−7 | | Day−1 | Saturation level of fractional tumor cell kill by TCD8 cells | 5.8 | 5.8 | | None | Exponent of fractional tumor cell kill by TCD8 cells | 1.36 | 1.36 | | None | Steepness coefficient of the tumor-TCD8 cells competition | 2.5 | 2.5 | | Cells day−1 | Constant source of NK cells | 1.3 × 104 | 1.3 × 104 | | Day−1 | Death rate of NK cells | 4.12 × 10−2 | 4.12 × 10−2 | | Day−1 | Maximum NK cell recruitment rate by tumor cells | 2.5 × 10−2 | 2.5 × 10−2 | | Cell2 | Steepness coefficient of the NK cell recruitment curve | 2.02 × 107 | 2.02 × 107 | | Cell−1 day−1 | NK cell inactivation rate by tumor cells | 1.0 × 10−7 | 1.0 × 10−7 | | Day−1 | Death rate of TCD8 cells | 2.0 × 10−2 | 2.0 × 10−2 | | Day−1 | Maximum TCD8 cell recruitment rate | 3.75 × 10−2 | 3.75 × 10−2 | | Cell2 | Steepness coefficient of the TCD8 cell recruitment curve | 2.0 × 107 | 2.0 × 107 | | Cell−1 day−1 | TCD8 cell inactivation rate by tumor cells | 3.42 × 10−10 | 3.42 × 10−10 | | Cell−1 day−1 | Rate at which tumor-specific TCD8 cells are stimulated to be produced as a result of tumor cells killed by NK cells | 1.1 × 10−7 | 1.1 × 10−7 | | Cells | Initial number of tumor cells | 100 | 100 | | Cells | Initial number of NK cells | 200 | 200 | | Cells | Initial number of TCD8 cells | 1000 | 100 |
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