Review Article
Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
Table 10
Dry powder coated lactose incorporated DPI formulations.
| Drug | Coating mechanism and coating time (min) | Key ingredients | PSD (μm) | Device and flow rate (l/min) | % FPF | References |
| SS | Wurster Fluidized Bed and 180 | Pharmatose 200 M and aqueous HPMC solution | 81.80 | Jethaler and 60 | | [100] | SS | Theta-Composer® and 10 | Pharmatose 200 M and MgSt (10%) | | Jethaler and 30 | ~40.00 | [99] | SS | Vortex-Mixer and 60 | Pharmatose 200 M and MgSt (2%) | 87.50 | Jethaler and 60 | | [101] | SS | Theta-Composer and 10
| Pharmatose 200 M and sucrose tristearate (10%) | | Jethaler and 60 | | [102] | TNRA | Rotor-type powder mixer (Mechanofusion) and 15 | Pharmatose 325 M and sucrose stearate (1%) | 90 | Jethaler and 30 | 20.90 | [103] | TNRA | Rotor-type powder mixer (Mechanofusion) and 15 | Pharmatose 325 M and MgSt (2%) | | Jethaler and 30 | 34.60 | [103] | SS | Rotor-type powder mixer (Mechanofusion) | MgSt (5%) | - | Monodose inhaler and 60 | 69.00 | [104] | Salmeterol xinafoate | Rotor-type powder mixer (Mechanofusion) | MgSt (5%) | - | Monodose inhaler and 60 | 73.10 | [104] |
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SS: salbutamol sulphate; MgSt: magnesium stearate; TNRA: triple neurokinin receptor antagonist; and FPF: fine particle fraction.
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